Central Pathways of Bladder. 4 marks ππ
1- Frontal Lobe Cortical Micturition Center (CMC)
Inhibits parasympathetic sacral micturition center
Controlling external urethral sphincter
Result in social inhibition and control of micturition
2- Pontine micturition center (PMC)
Coordinates bladder contraction and sphincter relaxation
3- Sacral Micturition Center (Pelvic and pudendal nuclei)
Micturition reflex mediated by parasympathetic sacral pelvic n. (S2βS4)
4- Motor cortex to pudendal nucleus
Voluntary control of external urethral sphincter
Cuccurollo 4th Edition Chapter 7 SCI pg566
Peripheral Efferent Pathways of Bladder. 3 marks ππ
1- SYMPATHETIC
Nerve
Hypogastric nerves (T11βL2)
Receptor & Location
Body of the bladder (Beta-2 adrenergic receptors)
Base of the bladder and prostatic urethra (Alpha-1 adrenergic receptors)
Neurotrasnmitter
Norepinephrine
Function
Beta adrenergic receptors within the body of the bladder causes smooth muscle relaxation (compliance)
Alpha adrenergic receptors within the base of the bladder/prostatic urethra causes smooth muscle contraction (increase outlet resistance)
Goal
Urine storage
2- PARASYMPATHETIC
Nerve
Pelvic nerves (S2βS4)
Receptors & Location
Bladder wall, trigone, bladder neck (Cholinergic muscarinic receptors)
Neurotrasmitter
Acetylcholine (Ach)
Function
Bladder contraction and emptying
3- SOMATIC
Nerve
Pudendal nerve (S2-S4)
Receptor
Cholinergic nicotenic receptors
Neurotrasmitter
Acetylcholine (Ach)
Function
Innervate striated muscle of external urethral sphincter.
Function
Voluntary contraction for preventing leakage or emptying
Cuccurollo 4th Edition Chapter 7 SCI pg566
Afferent Pathways of bladder. ππ
1- Pelvic nerve (parasympathetic)
Detrusor muscle stretch receptors
Bladder wall tension
Bladder mucosal nociception (pain, irretation)
2- Pudendal nerves
External anal and urethral sphincters, perineum, genitalia
Urethral mucosal sensation (pain, tempreture, passage of urine)
Cuccurollo 4th Edition Chapter 7 SCI pg568
Braddom 5th Edition Chapter 20 Bladder
Compare Urethral Sphincters (Nerve - Receptor - Type of Muscle - Function)ππ
INTERNAL SPHINCTER
EXTERNAL SPHINCTER
Cuccurollo 4th Edition Chapter 7 SCI pg568
You are meeting a patient with bladder dysfcuntion, explain to his how does the bladder work.
How does the bladder work when the spinal cord is intact? 3 marks. ππ (OSCE)
1- Urine Production
Urine produced by the kidneys passes through the ureters to fill the bladder. When the bladder is not full, the bladder wall muscle is relaxed. The bladder sphincter muscles are tightened so urine does not leak out.
2- Urine Storing
When there is enough urine to stretch the bladder walls, a nerve signal is sent up the spinal cord to tell the brain that the bladder is full. Because the brain controls the external sphincter muscle, urine can be held until an appropriate time to empty.
3- Urine Emptying
When the bladder is to be emptied, signals are sent from the brain down the spinal cord to cause the coordinated squeezing of the bladder wall muscle and relaxation of the bladder sphincter muscles to allow urine to pass through the urethra and out of the body.
Normal range of bladder volume and detrusor pressure. ππ (OSCE)
Bladder Sensation
Starts around 200ml up to 500ml where patient starts to feel urgency
Bladder Capacity
( Age + 1 ) x 30mL for < 12 years
500-700ml for 12+ years
Voiding Volume
Each void less than 500
Residual Volum
Less than 100
Detrusor pressure
5-10 mmH2O
> 40 mmH2O may harm the kidney
List the type of bladder dysfcuntion in each lesion site ππ
Rostral to (above) pons
Detrusor hyperreflexia with coordinated sphincters (UMN Bladder)
Between pons and sacral spinal cord
Detrusor hyperreflexia with sphincter dyssynergia (DSD)
Sacral spinal cord
Detrusor and sphincter areflexia (normal detrusor function with areflexic sphincter).
Cauda equina or peripheral nerves
Detrusor and sphincter areflexia.
UMN bladder. Causes, Lesion site, Presentation & Treatment. ππ
Causes
Sacral Reflex
Presentation
Treatment
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
DeLisa 5th Edition Chapter 7 SCI pg1358 Table 51.3
LMN bladder. 4 Causes (MOCK), Lesion site, Presentation & Treatment. ππ
Causes
Sacral Reflex
Presentation
Treatment
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
LMN bladder. 4 Causes (MOCK), Lesion site, Presentation & Treatment. ππ
Causes
Sacral Reflex
Presentation
Treatment
Cuccurollo 4th Edition Chapter 7 SCI pg572 Table 7-9
Braddom 5th Edition Chapter 20 pg436 Table 20-4
In detrusor areflexia (LMN bladder), why do some patients have difficulty emptying?
Internal sphincter tone is usually flaccid with LMN lesion, but may be intact due to sympathetic innervation, causing difficulty with complete emptying.
Ref: http://www.scireproject.com/case-studies/case-6-mr-r-b/neurogenic-bladder
List 8 reversible factors for incontinence ππ
ASIA A C8 increasing incontinence. 4 causes.
List 4 urodynamic and functional causes of incontinence in neurogenic bladder dysfunction
Caused by the bladder
Caused by the outlet
DeLisa 5th Edition Chapter 7 SCI pg1351 Table 51.2
DIAPPERS
DeLisa 5th Edition Chapter 51 Neurogenic Bladder & Bowel pg1353
List 4 classes of treatment for enhancing bladder volumes in hyper-reflexic bladder in SCI.
Collecting Devices
Pharma
Surgical
https://scireproject.com/wp-content/uploads/SCIRE_Bladder_V7.pdf
List 4 urodynamic and functional causes of retention in neurogenic bladder dysfunction
Caused by the bladder
Caused by the outlet
DeLisa 5th Edition Chapter 7 SCI pg1351 Table 51.2
Which drug will best lower urethral resistance?
Alpha-adrenergic antagonists (Omnic 0.4mg OD)
What is Detrusor sphincter dyssynergia (DSD)? When does it happen? π
Successful micturition reflex
Pontine micturition center (PMC)
Detrusor sphincter dyssynergia (DSD)
Neurological injury
Cuccurollo 4th Edition Chapter 7 SCI pg574
Braddom 5th Edition Chapter 20 Bladder pg429
What to monitor for patients with neurogenic bladder?
π‘ Blood - Imaging - Special Tests
Why SCI patients are at higher risk of developing CKD? 4 marks
π‘ Stone β Obstruct β Reflux β Bacteria
List 4 urinary complications seen in SCI
Cuccurollo 4th Edition Chapter 7 SCI pg576
Mention 4 UTI sign and symptoms in SCI patient
π‘ The symptoms of urinary tract infections are not always easy to recognize.
What test can be employed to differentiate prostatitis from pyelonephritis?
Elevated PSA (prostate-specific antigen) is seen in prostatitis
List 4 risk factors for UTI in SCI patient.
SCIRE
How do manage patient with positive urine culture? ππ (OSCE)
Asymptomatic UTIs
Exceptions
Symptomatic UTIs
Medication
Duration
Cuccurollo 4th Edition Chapter 7 SCI pg576
SCIRE
List 5 Urease-producing organisms ππ Dr. Abdulrazaq