6: Pharmacology of anxiolytics Flashcards Preview

Psychiatry Week 2 2018/19 > 6: Pharmacology of anxiolytics > Flashcards

Flashcards in 6: Pharmacology of anxiolytics Deck (17)
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1

Which drugs are used to control anxiety in the short term?

Benzodiazepines

2

fear symptoms - amygdala

worry symptoms i.e the feeling of anxiety - big ol long one

3

match parts of the brain to symptoms of anxiety

4

Which drugs enhance the action of GABA (inhibitory neurotransmitter)?

Benzodiazepines

5

Which inhibitory receptor is the main one acted on by benzodiazepines, barbiturates (used in the past) and alcohol?

GABA-A

6

Which ion passes through the cell membrane when GABA-A receptors are activated?

What is the effect on the membrane potential?

Cl-

Repolarisation

7

What binds to GABA-A receptors to open Cl- channels?

Benzodiazepines

8

What effect do benzodiazepines have on GABA-A receptors?

Allosteric

Open Cl- channels, repolarising cell, making it less likely to fire an AP

9

What are some examples of benzodiazepines used for sedation, anxiety and sleeping disorders?

Diazepam

Lorazepam

Chlordiazepoxide

10

What benzo is longer acting and so tends to be used in primary care?

Diazepam

11

Which

a) withdrawal state

b) neurological emergency

can benzos be used to treat?

a) Alcohol withdrawal

b) Status epilepticus

12

What are some of the side effects of benzodiazepine withdrawal?

GI - N&V, cramps

Anxiety symptoms

13

Are benzodiazepines addictive?

Yes

Also can build a tolerance to them

14

Can benzodiazepines be withdrawn immediately?

No > withdrawal

Switch to long acting (diaz or chloradiazepoxide) and taper dose

15

Apart from benzodiazepines, which other class of drug can be used to treat anxiety?

How does it work?

SSRI / SNRI

Inhibit reuptake of serotonin

16

Apart from benzodiazepines and SSRI/SNRIs, what drugs can be used to manage anxiety disorders?

Pregabalin

Gabapentin

17

basically every anxiety disorder is treated with psychological therapy > SSRI

go on to pregabalin for GAD

go on to TCA for panic disorder