Which drugs are used to control anxiety in the short term?
fear symptoms - amygdala
worry symptoms i.e the feeling of anxiety - big ol long one
match parts of the brain to symptoms of anxiety
Which drugs enhance the action of GABA (inhibitory neurotransmitter)?
Which inhibitory receptor is the main one acted on by benzodiazepines, barbiturates (used in the past) and alcohol?
Which ion passes through the cell membrane when GABA-A receptors are activated?
What is the effect on the membrane potential?
What binds to GABA-A receptors to open Cl- channels?
What effect do benzodiazepines have on GABA-A receptors?
Open Cl- channels, repolarising cell, making it less likely to fire an AP
What are some examples of benzodiazepines used for sedation, anxiety and sleeping disorders?
What benzo is longer acting and so tends to be used in primary care?
a) withdrawal state
b) neurological emergency
can benzos be used to treat?
a) Alcohol withdrawal
b) Status epilepticus
What are some of the side effects of benzodiazepine withdrawal?
GI - N&V, cramps
Are benzodiazepines addictive?
Also can build a tolerance to them
Can benzodiazepines be withdrawn immediately?
No > withdrawal
Switch to long acting (diaz or chloradiazepoxide) and taper dose
Apart from benzodiazepines, which other class of drug can be used to treat anxiety?
How does it work?
SSRI / SNRI
Inhibit reuptake of serotonin
Apart from benzodiazepines and SSRI/SNRIs, what drugs can be used to manage anxiety disorders?
basically every anxiety disorder is treated with psychological therapy > SSRI
go on to pregabalin for GAD
go on to TCA for panic disorder