8: Psychiatric genetics Flashcards Preview

Psychiatry Week 2 2018/19 > 8: Psychiatric genetics > Flashcards

Flashcards in 8: Psychiatric genetics Deck (13)
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1

What is the mode of inheritance of Huntington's disease?

Autosomal dominant

2

What are the chances of a child inheriting an autosomal dominant condition?

50%

3

What is anticipation?

As a mutated gene is passed down through generations, the presentation of the disease gets worse

e.g Huntington's (inherited CAG repeats)

4

What is the genetic cause of Huntington's disease?

Huntingtin gene mutates

CAG triplet repeats code for glutamine

You should have < 38, 32-38 may cause you to pass it on by anticipation, >38 means a definite onset of HD

5

What is the primary determinant of HD onset?

Number of CAG repeats (>38)

6

The more CAG repeats you have (over 38), the ___ your onset of Huntington's disease.

earlier

7

What is the course and prognosis of Huntingtons disease?

Unremitting, progressive course

Untreatable (only symptomatic), eventual death

8

What is the usual mode of inheritance of dementia?

Multifactorial

9

What features of the history indicate a patient has a familial form of a disease?

Unusual clinical features

More family members affected

Family members affected at a young age

10

What is your lifetime risk of developing Alzheimer's disease?

10%

11

If you have a first degree relative with Alzheimer's disease, what is your risk of developing the condition?

25%

12

What is the prevalence of bipolar type 1?

1%

13

What is the mode of inheritance of bipolar disorder?

Probably multifactorial