Exam 4: Dr. Archer Cyclosporine Therapy

Question 1

What cytokine is inhibited due to cyclosporine?

Answer 1

IL-2

Question 2

What are the monitoring options with cyclosporine therapy?

Answer 2

Therapeutic Drug Monitoring

Pharmacodynamics

Question 3

What is therapeutic drug monitoring?

Answer 3

Measurement of cyclosporine blood concentrations

Question 4

What is pharmacodynamics?

Answer 4

Measuring the biological effects of the drug on the target cell

Question 5

What is monitoring with cyclosporine used to do?

Answer 5

Help decide if a patient is being treated appropriately as well as if they might be at risk for secondary infections

Question 6

What is immune monitoring?

Answer 6

Measuring functional and molecular markers of immune reactivity to provide clinically useful information

Question 7

What is immune monitoring done through?

Answer 7

The identification of relevant biomarkers

Question 8

What is flow cytometry?

Answer 8

Use of antibodies to recognize extracellular and intracellular targets

Question 9

Describe PCR

Answer 9

Polymerase chain reaction
Looking at target sequences of nuclear material
Quantitative: quantitate the amount of target DNA