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S&D1 > Sulfa drugs-block1 > Flashcards

Sulfa drugs-block1 Flashcards

1
Q

Sulfamethoxazole and trimethoprim are the drugs of choice against?

A

Pneumocystis carinii pneumonia

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2
Q

Pyrimethamine and Sulfadoxine are the drugs of choice against what disease?

A

Malaria

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3
Q

What are the intermediate acting sulfa drugs?

A

Sulfadiazine, Sulfamethoxazole

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4
Q

What are the three adverse effects of sulfonamides?

A

Crystalluria, Hemolysis with G6PD, and Kernicterus (in neonates, contraindicated)
Kernicterus is jaundice in babies

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5
Q

Dihydropteroate sythetase is inhibited by what drug?

Dihydrofolate reductase is inhibited by what drug?

A

Sulfonamides

Trimethoprim

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6
Q

Pyrimethamine and Sulfadiazine are the drugs of choice against what?

A

Toxoplasmosis

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7
Q

What are the short acting and long term acting sulfonamides?

A

Long: Sulfadoxine

Short: Sulfisoxazole

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8
Q

What drug is used alone orally in acute UTI, not to mention prostatitis?

A

Trimethoprim

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9
Q

When fighting UTIs what is the drug of choice against of E. Coli?

A

Cotrimoxazole

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10
Q

What is the drug of choice against Pneumocystis carinii pneumonia (P. jeroveci)?

A

Cotrimoxazole

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11
Q

Sulfonamide that is acetylated will not move through acidic urine. What should the patient do to avoid crystalluria?

A

Drink plenty of water

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12
Q

What is the drug of choice against nocardia?

A

Cotrimoxazole

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13
Q

Sulfapyridine and Sulfasalazine are the drugs of choice against what? name two diseases

A

Ulcerative Colitis

and Rheumatoid Arthritis

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14
Q

Trimethoprim has what two adverse drug reactions?

A

Bone marrow suppression, Enterocolitis

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15
Q

What drug is the fixed dose combination of trimethoprim and sulfamethoxazole?
The fixed dose ratio is 1:5, what is the plasma concentration?
What metabolism pathway does this drug block?

A

Cotrimoxazole
1:20
Folate metabolism

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16
Q

What sulfa drug is used for eye infections?

What sulfa drug is used to fight bacteria, fungi, normally used in burn dressing, ulcers?

A

Sulfacetamide

Silver Sulfadiazine

17
Q

Diloxanide furoate, Iodoquinol, Paromomycin

are what kind of drugs?

A

Luminal Amebicidal Drugs, they act on the parasite in the lumen of the bowel (small and large intestine)

S&D1 (17 decks)

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