Digoxin

Question 1

mechanism of digoxin

Answer 1

causes vagus nerve to increase release of acetylcholine which then slows HR to decrease constant neuronal firing in atria/cardiac workload

also blocks NaKATPase pump to increase contractile force/decrease cardiac workload

Question 2

issues w/digoxin

Answer 2

eliminates symtpoms of heart failure but doesn’t protect against cardiac remodeling
NTI: 0.5-0.8 (ATI), 0.5-2 (union)
interactions: diuretics, ACE inhibitors, ARBs, antacids
hold if apical HR<60 for 60 sec; MUST listen, not palp

Question 3

early digoxin toxicity

Answer 3

V ommiting
A nnorexia
N ausea

Question 4

late digoxin toxicity

Answer 4

bradydisrhythmias
syncope
altered mental status
yellow/halo vision

Question 5

potassium and digoxin

Answer 5

inverse “K” relationship w/digoxin