HSV and influenza

Question 1

herpes simplex virus

Answer 1

vesicular lesions
lies dormant in nerves
mouth, face, eyes, CNS --> HSV 1
genitalila --> HSV 2
can be spread to baby via eyes

no cure

Question 2

HSV meds

Answer 2

HSV 1 and 2/herpes zoster:
acyclovir
valacyclovir - prodrug w/increased absorption

must drink H2O; taken at onset of sx

Question 3

issues w/HSV antivirals

Answer 3

HA, N/V, phlebitis (common)

crystal urea, altered mental status (rare)

Question 4

HSV meds mechnism of action

Answer 4

activated by viral enzyme

spares healthy human cells

Question 5

influenza vaccines

Answer 5

protection begins in 1-2wks
protection lasts 6mo (4 for elderly)
do NOT cause the flu

Question 6

flu med

Answer 6

oseltamivir

Question 7

mechanism of influenza

Answer 7

viral particles infect cell and an enzyme allows for release of viral particles into another cell

Question 8

oseltamivir mechanism of action

Answer 8

block neuraminidase enzyme from releasing viral particles into new cells

most effective EARLY on when viral particles not released

Question 9

issues w/oseltamivir

Answer 9

well-tolerated
N/V
take w/in 48h to decrease duration of sx
effective prophylactically, but not a substitute for vaccine