Antiemetics

Question 1

mechanism of vomitting

Answer 1

NTs from stomach or inner ear trigger N/V

Question 2

antiemetic meds

Answer 2

ondansetron
promethazine
metoclopramide

Question 3

ondansetron

Answer 3

blocks 5HT3 (no effect on anxiety etc)
“clean drug”
headache, D/constipation, dizziness, prolonged QT interval–>torsades–>vFib
works better if administered prophylactically

Question 4

promethazine

Answer 4

“dirty”
H1 block: sedation, dry mouth
D2 block: EPS
A1 block: orthostatic hypoTN

do NOT give to children<2yo
infiltration causes gangrene

Question 5

metoclopramide

Answer 5

blocks D2, 5HT3 and promotes gastric motility
EPS, drowsiness
do NOT take >3months