7 Histo of the SI + LI Flashcards

1
Q

Where a GI organ is covered in peritoneum, the outermost layer is called

A

Serosa

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2
Q

The small intestine is characterized by what kind of crypts

A

Lieberkuhn

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3
Q

What are the ways in which the SI functions to increase SA

A

Vili
Plica circularis (similar to rugae)
Microvilli (only found in SI)

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4
Q

What does the villus capillary plexus of the SI supply

A

Intestinal villus and upper portion of crypts of lieberkuhn

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5
Q

What does the pericryptal capillary plexus supply in the SI

A

Lower half of crypts of liberkuhn

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6
Q

What do lacteals do

A

They are lymphatic vessels that can form GALT and function to transport fats

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7
Q

Where is the plexus of meissner

A

Submucosa layer

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8
Q

Where is the myenteric plexus of auerbach

A

In between the inner circular muscularis layer and the outer longitudinal layer

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9
Q

What glands are characteristic of the duodenum

A

Brunner’s glands in the submucosa

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10
Q

What do bruner’s glands do

A

Produce an alkaline secretion to neutralize acidic stomach contents

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11
Q

What is a major characteristic of the gastroduodenal junction

A

Thick wall of muscle at the pyloric sphincter

Deep glands can be found in the duodenum

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12
Q

What does the jejunum’s villi look like

A

They are longer than the ileum and they have developed lacteals underneath

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13
Q

What is the difference between the jejunum and the duodenum

A

The jejunum lacks Brunner’s glands

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14
Q

What does the jejunum not have that the ileum has

A

Peyer’s patches (developed lymph nodules)

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15
Q

How do the villi of the jejunum and the ileum compare

A

Ileum has shorter and less plentiful villi

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16
Q

What parts of the GI have paneth cells

A

Ileum and jejunum

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17
Q

Where are paneth cells found in the ileum

A

Base of the crypts of lieberkuhn

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18
Q

What type of cells are found within SI glands and crypts

A

Enteroendocrine cells, paneth cells, intestinal stem cells

19
Q

What is the surface of microvilli sometimes called

A

Brush border

20
Q

What holds up the microvilli so they remain upright

A

Terminal web (cytoskeletal filaments)

21
Q

What cell type appear to have microvilli but do not?

A

Goblet cells

22
Q

The apical domain of goblet cells is characterized by what

A

Large mucus granules

23
Q

The basal domain of goblet cells is characterized by what

A

rER, golgi, and nucleus to ship all the mucus granules

24
Q

What is the function of intestinal mucus

A

Hydrates intestinal mucus and forms a protective coat to shield from abrasion and bacterial invasion

25
Q

What do the enteroendocrine cells of the SI secrete

A

Gastrin, secretin, cholecystokinin

26
Q

What does secretin do

A

Stimulates bicarb secretion by pancreas

Enhances insulin secretion by β cells in the islets of langerhans

27
Q

Wha does cholecystokinin do

A

Slows down emptying of stomach by acting on pyloric sphincter

Stimulates bile release from gallbladder and the secretion of pancreatic enzymes

28
Q

What does gastrin do

A

Stimulates secretion of hydrochloric acid by parietal cells

Stimulates insulin secretion

Stimulates gastric motility and growth of mucosal cells

29
Q

What are paneth cells

A

Pyramidal shaped cells that secrete anti-microbial proteins (defensins, lysozyme, angiogenin 4)

30
Q

What types of cells do intestinal stem cells produce

A

Goblet cells, enterocytes, enteroendocrine cells

31
Q

What is the function of the LI

A

Absorb water, Na, vitamins, minerals

Uptake of sedatives, anesthetics, steroids

32
Q

What are found in SI that are not found in the LI

A

Plicae circulares and intestinal villi

33
Q

Where are paneth cells found in the LI

A

Cecum

34
Q

What does the muscularis of the LI contain

A

Taeniae coli that form haustra

35
Q

What does the serosa of the LI contain

A

Appendices or fat tags related to a person’s weight

36
Q

How is the appendix different from the LI

A

The submucosa of appendix contains adipocytes and outer longitudinal layer is not well developed

37
Q

What is the cause of hirshprung’s disease

A

Missing myenteric or submucosal n plexuses

38
Q

What causes the aganglionosis in hirschprung’s disease

A

Failure of NCC to develop

39
Q

What mutation causes the aganglionosis of hirschprung’s disease

A

RET gene encoding a RTK

40
Q

What does the RET gene do in the colon

A

Required for:

  • formation of peyer’s patches
  • migration of NCC to LI
  • differentiation of neurons in enteric NS
41
Q

What does a biopsy from hirschprung’s show

A

Thick, irregular nerve bundles and abundant AChE staining

42
Q

The upper part of the rectum is characterized by what? Lower part

A

Mucosa and tubular glands

8-10 rectal/anal columns forming anal valves
-base of anal columns is pectinate line

43
Q

What cell types are found at the pectinate line?

A

Proximal - simple columnar

Distal - stratified squamous

44
Q

What is the skeletal muscle in the anal sphincter

A

External anal sphincter