Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Robbins Pathology GI (Chptr 16,17,18,19) > Clinical- IBD > Flashcards

Clinical- IBD Flashcards

1
Q

Overall, what is the result of irritable bowel disease

A

Increased permeability of the epithelium of the gut

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the immunogenetics component to IBD

A

HLA-DR2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the gene association with IBD

A

CARD15/NOD2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which antibody is commonly associated with Ulcerative colitis

A

ANCA (antineutrophil cytoplasmic antibodies)

*Notice the relation to PSC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What antibody is commonly associated with Crohn disease

A

ASCA (anti Saccharomyces cerevisiae)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the main therapies for IBD

A

-5-aminosalicylic acid, corticosteroids, immunomodulating agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the common other conditions seen with IBD

A

Peripheral arthritis
Erythema nodosum, pyoderma gangrenosum (especially with UC)
Thrombolytic effects (DVT)
Renal stones with urate or calcium oxalate (especially with crohns)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which IBD condition has non-caseating granulomas

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What condition is characterized by the “cobblestone”appearance

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which condition commonly has “creeping fat”

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What other condition commonly has non caseating granulomas

A

Sarcoidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which of the IBD commonly has pseudopolyps

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which IBD commonly has granulomas

A

Crohn disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which of the IBD will commonly have bloody diarrhea

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which IBD is commonly seen to have fulminant colitis

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is fulminant colitis

A

Severe disease characterized by rapidly worsening symptoms with signs of toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which IBD is commonly seen to have defects on growth

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which IBD is commonly seen to have acute ileitis mimicking appendicitis

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which IBD is commonly seen to have anorectal fissures, fistula, abscesses

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which IBD is commonly seen to have toxic megacolon

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Which IBD is commonly seen to have intestinal obstruction

A

Crohns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which IBD is commonly seen to have a reduced risk after having a appendectomy before age 20

A

UC

23
Q

Which IBD commonly presents following cessation of smoking

A

UC

24
Q

What is the key to diagnosis for UC

A

Sigmoidoscopy

25
Q

What is the key to diagnosis in Crohns

A

Sigmoidoscopy, curium edema, Upper GI and small bowel series

26
Q

UC is commonly seen to have what lab findings

A

Increased sedimentation rate/CRP
Increased fecal calprotectin levels
Anemia

27
Q

Crohns is commonly found to hav which lab findings

A

Hypoalbuminemia

Anemia

28
Q

Which IBD is commonly seen to have edema, friability, mucous, and erosions

A

UC

29
Q

Which IBD is commonly seen to have lead pipe on barium swallows

A

UC

30
Q

Which diagnostic test should not be run on UC and what is the reasoning

A

Colonoscopy due to the risk of perforation

31
Q

What is te diagnostic test order for Crohns

A

Colonoscopy and a biopsy

32
Q

What are the biopsy findings in Crohn’s disease

A

Skip lesions with stellate ulcers, stricture, and segmental involvement of healthy tissue followed by unhealthy

33
Q

Granulomas on biopsy is indicative of which IBD

A

Crohns

34
Q

In the complication of Crohns with an abcess, what is the process

A
  • Usualy presents with a fever and leukocytosis
  • Emergent CT
  • Broadspectum antibiotics
  • Percutaneous drainage or surgery
35
Q

What is the indication or finding in an intestinal obstruction in crohns

A

Intravenous fluids with nasogastric suction

36
Q

What is the diet given for patients with obstructive due to crohns

A

-Low roughage diet (aka no raw fruits, veggies, popcorn, nuts)

37
Q

What is the presentation of retroperitonieal phlegmon or abcess

A

Fevers, chills, tender ab mass, leukocytosis

38
Q

What is the fistula between the small intestine and colon called

A

Enterocolonic

39
Q

What is the presention of a entercolonic fistula

A

Usually asymptomatic, but can have diarrhea, weight loss, bacterial overgrowth

40
Q

What is the names of the fistulas that form with the bladder

A

Colovesical (colon to bladder)

Enterovesical (Small intestine to bladder)

41
Q

What is the symptom associated with fistulas connecting to the bladder

A

Recurrent urinary infection

42
Q

What is the symptom of a fistula with the vagina

A

Malodorous drainage and problems with hygiene

43
Q

What is the cause of cutaneous fistulas

A

Surgical scars

44
Q

Which IBD is commonly seen to have perianal disease

A

Crohn

45
Q

What is perianal disease characterized by

A

Skin tags, anal fissures, perianal abscesses, fistulas

46
Q

What is the best way to treat perianal disease

A

With a colorectal surgeon and using an MRI

47
Q

Which IBD is commonly seen to have severe hemorrhage

A

Crohns

48
Q

When there is the resection of the terminal ileum, what can occur

A

Reduced resorption of the bile acids, leading to secretory diarrhea

49
Q

Patients with extensive ideal disease should not be given which compounds and what are commonly associated with it

A

Should not be given bile salt binding agents, as it can cause diarrhea, as well as kidney stones

50
Q

What are the side effects of administering glucocorticoids for IBD

A

-mood changes, insomnia, buffalo hump, weight gain (striae), moon faces

51
Q

What are the side effects of 5-ASA

A

Aka aspirin

-Acute interstial nephritis

52
Q

What should always be administered with AZO components

A

-Folate

53
Q

What should always be tested for before administration of azathioprine or 6-MP

A

-TPMT or thiopurine methyltransferase

Robbins Pathology GI (Chptr 16,17,18,19) (32 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions