MODY Flashcards
MODY is autosomal dominant/recessive
MODY is autosomal DOMINANT
MODY is insulin/non-insulin dependent
MODY is NON-INSULIN DEPENDENT
MODY age of onset is before what?
25
heterozygous glucokinase mutations cause what?
MODY2
what is termed the ‘pancreatic glucose sensor’?
glucokinase
name the 2 distinct phenotypes of MODY
glucokinase and transcription factor (HNF-1alpha)
glucokinase mutation or transcription factor mutation?
Onset at birth
Stable hyperglycaemia
Diet treatment
Complications rare
glucokinase mutation
glucokinase mutation or transcription factor mutation?
Adolescence/young adult onset
Progressive hyperglycaemia
1/3 diet, 1/3 OHA, 1/3 Insulin
Complications frequent
transcription factor mutation
do you need insulin in glucokinase MODY?
NO!
state the most common type of HNF mutation in MODY
HNF-1alpha MODY
those with neonatal diabetes (rare) require _______ treatment within the first _ months of life
those with neonatal diabetes (rare) require INSULIN treatment within the first 3 months of life
name the 2 types of neonatal diabetes
transient neonatal diabetes - TNDM
permanent neonatal diabetes -PNDM
TNDM or PNDM:
diabetes diagnosed <1 week
resolves in 12 weeks
stop insulin
TNDM
TNDM or PNDM:
diabetes diagnosed 0-6 weeks
lifelong insulin treatment
PNDM
HNF-1alpha treatment?
SU sensitive
