Thiamin revision questions - week 10 Flashcards
1
Q
Food source
A
pork whole grain cereals eggs nuts legumes
2
Q
Absorption
A
- In SI (active transport or passive diffusion)
- present in food as free thiamin (plant) or Thiamin Pyrophosphate (TPP) (animal) - HCL required to free TPP from protein foods
- only free thiamin absorbed
- conversion to TPP in liver
3
Q
Transport
A
in red blood cells as TPP (coenzyme form)
4
Q
Storage
A
Minor storage - in liver and muscles
5
Q
Excretion
A
filtered rapidly by kidneys and excreted via urine
6
Q
Activation
A
?
7
Q
Main function
A
coenzyme in carbohydrate metabolism and energy release
TPP - decarboxylation
8
Q
RDI
A
men - 1.2 mg
women - 1.1 mg
9
Q
UL
A
none
10
Q
Toxicity
A
none
11
Q
Deficiency
A
Beriberi
- dry: nervous and muscular system malfunction (peripheral neuropathy)
- wet: nervous and muscular system malfunction and cardiovascular system malfunction e.g. congestive heart failure
Wernicke-korsakoff syndrom
- cerebral beriberi in alcoholism
- symptoms - double vision, cross eye, ataxia, constant shake, impaired mental function
