Copper revision - week 12

Question 1

Absorbed

Answer 1

• In SI
• 12-70%
• decreased with arge intake of Cu, Fe and Zn, phytates

Question 2

Transported

Answer 2

• Bound to protein eg. Albumin – taken to liver

- Released to other tissues from liver bound to ceruloplasmin

Question 3

Stored

Answer 3

liver and kidney

Question 4

Excreted

Answer 4

bile and faeces

Question 5

Major function

Answer 5

Aids in

• iron metabolism (by cofactor of ceruloplasmin)
• works in antioxidant enzymes (cofactor to superoxide dismutase)
• energy metabolism (cofactor to cytochrome C)
• regulation of neurotransmitters (cofactor of monoamine oxidase enzymes)
• is involved in formation connective tissue

Question 6

Food source

Answer 6

Liver, cocoa, nuts, whole grains, shellfish

Question 7

Deficiency

Answer 7

• Anemia – low white blood cell
• Loss of hair and skin pigmentation
• Lou gehrid disease

Question 8

Toxicity

Answer 8

Wilsons disease - copper build up

• Liver cirrhosis due to resulting excessive oxidative stress
• Neurological/psychiatric manifestations