Inflammation and Repair

Question 1

Cite the proper sequence of Recruitment of Leukocytes to sites of inflammation

Answer 1

Margination, Rolling, Adhesion, Transmigration (Diapedesis), migration

Question 2

Interleukin that mediates leukocyte recruitment

Answer 2

IL 1

Question 3

___ is a leukocyute-endothelial process that is weak, transient,

Answer 3

Rolling

Question 4

____ is the main adhesion molecule during diapedesis

Answer 4

CD31/PECAM-1

Question 5

Endogenous compounds that play a role in chemotaxis

Answer 5

IL-8, C5a, LTB4

Question 6

What is the dominant infiltrate during a pseudomonas infection

Answer 6

PMNs for several days

Question 7

What is the ligand of selectins?

Answer 7

Sialyl-Lewis X

Question 8

Cite 3 examples of removing the pathologic agent

Answer 8

Intracellular (ROS, NO)
Lysosomal enzymes
Neutrophil extracellular traps (NETs)

Question 9

____ are anti-inflammatory cytokines

Answer 9

Lipoxin (AA metabolite)
TGF beta
IL 10

Bega10 = mataba = lipid = lipoxin

Question 10

____ is found in platelets and neuroendocrine cells that is a potent vasoconstrictor

Answer 10

Serotonin (derived from tryptophan)

Question 11

The enzyme cyclooxygenase produces ___ and ____ from AA

Answer 11

Prostanoids (Vasodilators)

Thromboxane (Vasoconstrictor)

Question 12

____ are eicosanoids that increases vascular permeability and causes bronchospasm

Answer 12

LTC4, D4, E4

Inhibited by LTRAntagonist

Question 13

___ prostanoids that causes vasodilation, and inhibits platelet aggregation

Answer 13

Prostacyclin (PGI2)

Question 14

___ prostanoids that causes vasoconstriction, promotes platelet aggregation

Answer 14

Thromboxane A2

TXA2 = X = shrink

Question 15

___ prostanoids that causes vasodilation, increases vascular permeability

Answer 15

PGD2, PGE2

PGD = drains

Question 16

Cytokine that plays a role in acute inflammation specifically in recruiting neutrophils and monocytes

Answer 16

IL 17

Question 17

Cytokine in chronic inflammation that acts on macrophages and dendritic cells resulting to increased production of IFN gamma

Answer 17

IL12

Question 18

____ pathway in complement system in which C1 binds to Ig-Ag complex

Answer 18

classical

Question 19

___ pathway in complement system that depends on microbial components

Answer 19

alternative

Question 20

___ is the most abundant component in complement systems

Answer 20

C3

Question 21

Anaphylatoxins in complement pathway which promotes histamine release from mast cells

Answer 21

C3a, C5a

C5a are chemoattractants to neutrophils, monocytes, eosinophils and basophils

Question 22

Component of complement pathway that are part of MAC

Answer 22

C5b, C6-9

Question 23

Cytokines that plays a role in endothelial activation, fever, hypotension, and metabolic abnormalities

Answer 23

TNF, IL-1, IL-6

Question 24

___ is the hallmark of granuloma formation

Answer 24

presence of epithelioid cells or giant cells

Question 25

IL 6 dominates during an acute phase response. This will lead to increase in

Answer 25

CRP, Fibrinogen, Amyloid A

Question 26

___ is the most important cytokine for synthesis and deposition of connective tissue

Answer 26

TGF-beta

Question 27

[Abnormalities in tissue repair]

Inadequate formation of granulation tissue

Answer 27

Wound dehiscence

Question 28

____ is the excessive formation of repair components extending beyond the border of the lesion

Answer 28

keloid