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Pathology > WBC, LN, Spleen > Flashcards

WBC, LN, Spleen Flashcards

1
Q

cut off value for clinically significant neutropenia

A

<500/mm3

considered agranulocytosis

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2
Q

most common cause of agranulocytosis

A

drug toxicity

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3
Q

___ syndrome is associated with inadequate of ineffective granulopoiesis

A

kostmann syndrome

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4
Q

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

A

myelodysplastic syndrome

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5
Q

___ center is the area of B-cell activation

A

germinal center

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6
Q

___ zone contains small, naive B cells in LN

A

mantle zone

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7
Q

pattern of hyperplasia seen in acute viral infections; mottled appearance

A

paracortical hyperplasia

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8
Q

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

A

Acute leukemia

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9
Q

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

A

chronic leukemia

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10
Q

sanctuary sites of Bcell ALL and T cell ALL

A

testis

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11
Q

this refers to absence of blasts in peripheral blood; >100,000/mm3

A

aleukemic leukemia

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12
Q

t(15;17)

A

APML

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13
Q

t(12;21)

A

B-CELL ALL

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14
Q

NOTCH-1 mutation

A

T-CELL ALL

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15
Q

[diagnosis]

needle-like azurophilic granules

A

APML

auer rods

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16
Q

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

A

faggot cells

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17
Q

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

A

CLL

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18
Q

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

A

SLL

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19
Q

Chronic lymphomas that can undergo Richter Syndrome

A

CLL, SLL

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20
Q

progression of CLL to DLBCL is called

A

richter syndrome

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21
Q

t(9;22)

A

CML

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22
Q

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

A

CML

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23
Q

[diagnosis of CML phase]

  1. Increasing WBC unresponsive to therapy
  2. Basophils >20%
  3. Thrombocytes <100,000 unrelated to therapy OR
  4. > 1,000,000 unresponsive to therapy
  5. increasing splenomegaly
A

Accelerated phase

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24
Q

____ (low/high) leukocyte alkaline phosphatase level in CML

A

low

25
Q

receptor used by drugs in treating CML

A

Tyrosine Kinase

DOC: imatinib

26
Q

[diagnosis]

LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

A

Hodgkin lymphoma

27
Q

[subtype of HL]

Reactive T-cells with fibrous bands forming nodules, not associated with EBV

A

nodular sclerosis

28
Q

[subtype of HL]

mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

A

mixed cellularuty

29
Q

[subtype of HL]

rich reactive T-cell infiltrate, 40% associated with EBV

A

lymphocyte rich

30
Q

[subtype of HL]

rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

A

lymphocyte depleted

31
Q

[subtype of HL]
reactive B cells, popcorn reed steinberg cells, not associated with EBV

CD15 (-)
CD30 (-)
CD20 (+)

A

Lymphocyte predominant

32
Q

staging system used in hodgkin lymphoma

A

ann arbor classification

33
Q

most common indolent lymphoma of adults

A

follicular lymphoma

34
Q

[diagnosis]
painless, generalized lymphadenopathy,

BMA: paratrabecular lymphoid aggregates, can undergo richter syndrome

transform to DLBCL or Burkitt lymphoma

A

Follicular lymphoma

35
Q

[diagnosis]

LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

A

Hodgkin lymphoma

36
Q

[diagnosis]

LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation,

mesenteric and waldeyer ring are commonly involved

A

non-hodgkin lymphoma

37
Q

most common lymphoma of adults

A

Diffuse large B-cell lymphoma

38
Q

[diagnosis]

approx 60/M rapidly enlarging mass at nodal or extranodal site,
histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

A

DLBCL

39
Q

Immunostains used in DLBCL

A

CD45, Cytokeratin, vimentin

40
Q

fastest growing human tumor

A

Burkitt lymphoma

41
Q

[diagnosis]

children/young adults, mandibular mass, 100% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

A

Endemic burkitt

42
Q

[diagnosis]

children/young adults, ileocecum, peritoneal mass, 15-20% latent infection with EBV

Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

A

Sporadic burkitt

43
Q

t(8;14) mutation

A

burkitt lymphoma

44
Q

[diagnosis, type of NHL]

type of lymphoma that can arise in salivary glands (sjogren syndrome), thyroid gland (hashimoto thyroiditis), stomach (H. pylori)

A

marginal zone lymphoma

45
Q

[diagnosis]

infiltration of epidermis and upper dermis T cells with cerebriform nuclei

A

mycosis fungoides/Cutaneous T cell lymphoma

46
Q

____ syndrome associated with mycosis fungoides characterized as generalized exfloative erythroderma and leukemia T-cells with cerebriform nuclei

A

Sezary Syndrome

47
Q

[diagnosis]

65-75 years old, PAS(+) cytoplasmic (russel bodies) or nuclear inclusion (dutcher bodies) containing Ig

A

Multiple myeloma

48
Q

[diagnosis]

punched out bone lesions, bence-jone proteinuria, hypercalcemia

A

Multiple myeloma

49
Q

[type of MDS]

Prussian blue (+) iron-laden mitochondria in erythroblast, megaloblastoid maturation, nuclear budding, abnormalities, mishapen polypoid nuclei

A

erythroid MDS

50
Q

[type of MDS]

presence of PMNs with only 2 lobes

A

granulocytic MDS

pseudo pelger huet cell

51
Q

[diagnosis]

pseudo Pelger Huet Cell

A

Granulocytic MDS

52
Q

[type of MDS]

megakaryocyte with multiple separated nuclei

A

megakaryocytic MDS

53
Q

[diagnosis]

pawn ball megakaryocyte

A

megakaryocytic MDS

54
Q

[diagnosis]

JAK2 mutation

plethoric, thrombosis, infarcts, hemorrahge, hyperuricemia, gout, throbbing and burning of hands and feet due to thrombotic occlusion by platelet aggregates

A

PV

55
Q

[diagnosis]

Thrombosis, infarcts, hemorrhage, escape of erythroid and granulocytic precursos into circulation and sites of extramedullary hematopoiesis

A

Essential Thrombocytopenia

56
Q

[diagnosis]

extensive deposition of collagen in marrow by non-neoplastic fibroblasts; WBC and platelet predominance, pronounced hepatosplenomegaly, hyperuricemia/gout,

presence of dacrocytes, fibrotic marrow converted into bone, osteo sclerosis

A

Primary myelofibrosis

57
Q

[diagnosis]

proliferative disorder of dendritic cells in skin, presence of birbeck granules, presence of racket shaped granules

A

langerhands histiocytosis

58
Q

[diagnosis]

birbeck granules, pentalaminar racket-shaped granules

A

langerhans histiocytosis

Pathology (36 decks)

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