Flashcards in 9.6 Synaptic plasticity, memory and learning Deck (15)
What is memory?
The encoding, storage and retrieval of learned information
What is declarative memory?
items available to consciousness and can be expressed by language
What is non declarative memory?
items not directly available to consciousness - skills, learning, cues
Difficult to express how such procedures are enacted
What are the temporal categories of memory?
How do you transfer information from working to long term memory?
What is anterogade and retrograde amnesia?
Anterograde: inability to create new memories
Retrograde: Inability to retrieve made memories
What causes anterograde amnesia?
Large correlation with hippocampal damage as this is important in formation of memory, processing for consolidation but NOT the site of storage
Where are declarative memories stored?
All over - distributed within networks which means that in general damage to one area wont lead you to losing everything
What happens in Wernickes aphasia?
inability to link sound with meaning of the word
What systems are involved in non declarative memory?
Basal ganglia, prefrontal cortex, cerebellum, amygdala and somatosensory cortex
what type of sleep is helpful for memory consolidation?
non REM sleep in stage 2 particularly in 4th quarter (towards morning)
How is sleep thought to help consolidation?
The same activity that occurs during a task continues on during sleep at very high correlations
During sleep hippocampal information is gradually synchronised with the cortex
What is synaptic plasticity?
Changes in synaptic efficacy, including post synaptic excitability and spine/cellular growth
How does long term potentiation occur?
1. AP depolarises terminal releasing glutamate
2. Glutamate binds to AMPA
3. Depolarisation which moves Mg
4. NMDA opens
5. Calcium enters the cell
6. Activates protein kinase C and Ca calmodulin kinase II
7. Insertion of additional AMPA receptors