A02 biological therapies for schizophrenia Flashcards Preview

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Flashcards in A02 biological therapies for schizophrenia Deck (33)
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1
Q

What are the 6 sections

A
Effectiveness of conventions anti psychotic drugs
Appropriateness
Effectiveness of atypical
Appropriateness
Effectiveness of ect
Appropriateness
2
Q

What are the 2 section some effectiveness of conventional anti psychotics

A

Relapse rate

Other factors are important

3
Q

Who tested relapse rate for effectiveness of conventional anti psychotics

A

Davis et al

4
Q

What did Davis et al do and find

A

A significant difference in relapse rate between treatment with a placebo drug and a convention anti psychotic drug

5
Q

Conclusion for relapse rate

A

Evidence shows that this type of medication is a useful therapy for schizo

6
Q

Who tested other factors as being important in effectiveness of conventional

A

Davis et al

7
Q

What did Davis et al fibd for other factors as being important in effectiveness of conventional

A

Difference ib terms of relapse rates between placebo and conventional drugs only evident in schizos living in homes with hostility and criticism (50% relapse rate with conventional, 92% with placebo)
In normal homes there’s no difference 12 & 15% relapse rates

8
Q

Conclusion of other factors are important

A

Evidence shows that due to difference when in different environment other factors are important in term so effectiveness of conventional anti psychotics so although anti psychotics may be used as a the road, they aren’t the only contributory factor for schizo therapy

9
Q

What are the sections for the appropriateness of conventional anti psychotics

A

Tardive dyskinesia

Motivational deficits

10
Q

Who studied tardive dyskinesia

A

Hill

11
Q

What did hill find

A

About 30% of people taking conventional develop tardive dyskinesia which is irreversible in 75% of cases

12
Q

Conclusion from hills study and tardive dyskinesia in terms of appropriateness of conventional

A

Conventional drugs lead to side effects so are they appropriate for treating schizo? No

13
Q

Who evaluated motivational deficits

A

Ross and read

14
Q

What did ross and read argue

A

That being prescribed medication reinforces the view that ‘there is something wrong with you’
This prevents indvs from thinking about possible stressors

15
Q

Conclusion for motivational deficits in terms of appropriateness of conventional

A

Due to them not thinking about possible stressors, there motivation to look for solutions that alleviate the stressors and decrease their suffering decreases
Suggests conventional may not be appropriate for schizo therapy

16
Q

What are the 2 sections for the effectiveness of atypical

A

Atypical vs conventional anti psychotics

Effectiveness with negative symptoms

17
Q

Who tested atypical vs conventional anti psychotics

A

Leucht et al

18
Q

What did leucht et al do and find

A

Meta analysis of studies comparing effectiveness of a typical and conventional drugs
Found 2 atypical drugs slightly more effective
2 other atypical drugs no more effective than conventional

19
Q

Conclusion for atypical vs conventional drugs in terms of effectiveness of atypical

A

Atypical drug effectiveness only slightly better but no major difference
Still means they’re useful therapies for schizo

20
Q

Who tested effectiveness with negative symptoms in terms of effectiveness of atypical

A

Leucht et al

21
Q

What did leucht et al do for effectiveness of negative symptoms

A

Found 2 atypical drugs to be slightly more effective with negative symptoms than conventional
But found 2 others, one as effective, one slight worse than conventional for effectiveness with negative symptoms

22
Q

Conclusion for effectiveness with negative symptoms in terms of effectiveness of atypical

A

Not much evidence to show it’s effective with negative symptoms
Some studies even suggest conventional os slightly better but overall still can be used as a the road but can’t support idea that it is useful to combat negative symptoms

23
Q

What are the 2 sections for the appropriateness of atypical

A

Lower likelihood of tardive dyskinesia

Fewer side effects

24
Q

Who tested the lower likelihood of tardive dyskinesia

A

Jeste et al

25
Q

What did jeste do and find

A

TD rates 30% in patients using conventional

But only 5% in patients using atypical

26
Q

Conclusion if lower likelihood of TD in terms of appropriateness of atypical

A

Evidence supports claim atypical has lower levels of side effects eg TD
Therefore it’s more appropriate to use for schizo therapy

27
Q

Explain and shit about the fewer side effects part of appropriateness of atypical

A

Atypical shown to have lower leveks and fewer side effects
This means they could be argued to be a more appropriate treatment for schizo
They also mean it’s less likely for schizos to stop using the medication due to fewer side effects compared to conventional anti psychotics

28
Q

What does research show in terms of effectiveness of ect from an American psychiatric association review when comparing ect and simulated ect effectiveness

A

Ect produced results that were no different or worse than anti psychotic drugs

29
Q

Who studied effectiveness of ect other than that American thing

A

Sarita et al

30
Q

What did sarita et al do and find in terms of effectiveness of ect

A

No difference in terms of symptom reduction in patients given either ect or simulated ect

31
Q

Conclusion for effectiveness of ect

A

Not very effective compared to anti psychotic drugs

32
Q

Conclusion for appropriateness of ect

A

Due to fact ect can be very harmful due to side effects and can even lead to death which very unlikely when using anti psychotic drugs it’s more appropriate to use anti psychotic drugs as a treatment for schizo

33
Q

What is reads study relevant to in terms of appropriateness of ect

A

Found that ect is being used very rarely

Decline of its use from 1979 to 1999 dropped increased by 59%