ABO/H/Secretor/Lewis

Question 1

ABO antigens detected on embryos at ___ age

Answer 1

5-6 weeks

Question 2

ABO antigens on chromosome __

Answer 2

9

Question 3

H antigen substrate

Answer 3

fucose

Question 4

formation of A, B, and H antigens results from interactions of genes on 3 separate loci: __, __, ___

Answer 4

ABO, Hh, Se

Question 5

H gene

Answer 5

FUT1

Question 6

Secretor gene (Se)

Answer 6

FUT2

fuctosyltransferase

Question 7

H and Se genes located on chromosome ___

Answer 7

19

Question 8

active secretor gene

Answer 8

Se

Question 9

inactive secretor gene

Answer 9

se

Question 10

Se/se gene frequency

Answer 10

80% secretors (SeSe or Sese)

20% non-secretors (sese)

Question 11

inheritance of Se gene results in ____ added to ____ chains resulting in type 1 H antigen substances in secretions

Answer 11

fucose/type1

Question 12

inheritance of H gene results in ___ added to ____ chains resulting in type 2 H antigens on red blood cells

Answer 12

fucose/type 2

Question 13

H gene transferase

Answer 13

alpha-2-L-fucosyltransferase

Question 14

A gene transferase

Answer 14

alpha-3-acetryl-galactosaminyl-transferase

Question 15

B gene transferase

Answer 15

alpha-3-D-galactosyltransferase

Question 16

O gene transferase

Answer 16

none; gene is non-functional

Question 17

oligosaccharide chain linkage in secretions

Answer 17

beta 1-3

Question 18

oligosaccharide chain linkage on red cells

Answer 18

beta 1-4

Question 19

A1 subgroup frequency

Answer 19

80% of A population

Question 20

A2 subgroup frequency

Answer 20

20% of A population

Question 21

anti-A1 lectin

Answer 21

Dolichos biflorus

Question 22

expected reaction of A1 cells with Dolichos biflorus

Answer 22

positive

Question 23

Ax subgroup presentation

Answer 23

no reaction with anti-A
weak reaction with anti-A,B
may produce anti-A1

Question 24

Am subgroup presentation

Answer 24

no reactions with anti-A or anti-A,B

Question 25

Aend subgroup presentation

Answer 25

weak reactions with anti-A and anti-A,B

Question 26

Ael subgroup presentation

Answer 26

no reactions with anti-A or anti-A,B but eluates contain anti-A

Question 27

Ay subgroup presentation

Answer 27

no reactions with anti-A, anti-A1, or anti-A,B

Question 28

B3 subgroup presentation

Answer 28

+/mf anti-B +/mf anti-A,B no anti-B in serum secretes H

Question 29

Bx subgroup presentation

Answer 29

0/+ anti-B 0/++ anti-A,B no anti-B in serum secretes B and H

Question 30

Bm subgroup presentation

Answer 30

+/++ anti-B +/++ anti-A,B anti-B in serum secretes B and H

Question 31

arises from inheritance of nonfunctional FUT1 gene, recessive genotype hh, and nonfunctional Se gene

Answer 31

Bombay phenotype

Question 32

Bombay phenotype types as ___

Answer 32

O

Question 33

Bombay phenotype rare disease association

Answer 33

Leukocyte Adhesion Deficiency 2 (LAD2) -- lack of fucose

Question 34

Bombay phenotype antibodies in serum

Answer 34

anti-A anti-B anti-H

Question 35

Bombay phenotype secretor status

Answer 35

non-secretor

Question 36

Para-Bombay secretor status

Answer 36

secretor

Question 37

Para-Bombay phenotype presentation

Answer 37

H-deficient secretors | homozygous for nonfunctional H gene but inherit at least 1 normal functional secretor gene

Question 38

para-Bombay phenotype serum reactions

Answer 38

anti-H and/or anti-IH

Question 39

lectin

Answer 39

plant seed extract that agglutinates human red cells with high degree of specificity

Question 40

anti-H lectin

Answer 40

Ulex europaeus

Question 41

isoagglutinins

Answer 41

term reserved for expected antibodies in ABO system

Question 42

alloantibodies

Answer 42

individual that has the antibody will not have the corresponding antigen

Question 43

ABO antibody type

Answer 43

IgM

Question 44

anti-A,B

Answer 44

formed by group O individuals and present in fairly high concentrations

Question 45

anti-A,B antibody class

Answer 45

IgG and IgM

Question 46

ABO antibody most likely in ABO HDN

Answer 46

anti-A,B

Question 47

anti-A,B HDN

Answer 47

group O moms make IgG anti-A,B when carrying group A or B baby

Question 48

autoantibody produced by group A1 and A1B

Answer 48

anti-H

Question 49

H antigen expression on blood types

Answer 49

O > Ax > A2 > B > A2B > A1 > A1B > Oh

Question 50

blood group with most H antigen expression

Answer 50

O

Question 51

(normal) blood group with least H antigen expression

Answer 51

A1B