Duffy and Kidd

Question 1

Duffy system chromosome

Answer 1

1

Question 2

gene responsible for FY antigen

Answer 2

ACKr1 (atypical chemokine receptor 1)

Question 3

Fya amino acid

Answer 3

glycine

Question 4

Fyb amino acid

Answer 4

asparagine

Question 5

Duffy antigens on cord cells?

Answer 5

yes

Question 6

effect of ficin and papain on Fya and Fyb antigens

Answer 6

destroyed

Question 7

effect of thiol reagents on Fya and Fyb antigens

Answer 7

not affected

Question 8

Duffy antigen present when Fya or Fyb present

Answer 8

Fy3, Fy5, Fy6

Question 9

effect of enzymes, pronase, DTT, acid on Fy3

Answer 9

resistant

Question 10

Duffy antigen that requires normal Rh for expression

Answer 10

Fy5

Question 11

Duffy antigen not expressed on Rh null cells

Answer 11

Fy5

Question 12

effect of enzymes, pronase, DTT, acid on Fy5

Answer 12

resistant

Question 13

cells negative to which Duffy antigen are resistant to P. knowlesi and P. vivax but not P. falciparum?

Answer 13

Fy6

Question 14

effect on ficin/papain, pronase on Fy6

Answer 14

destroyed

Question 15

effect of trypsin, DTT, acid on Fy6

Answer 15

resistant

Question 16

gene mutation where Duffy antigens are not expressed on red cells but are expressed on tissues

Answer 16

Fy(a-b-)

Question 17

Duffy phenotype that provides resistance to P. vivax and P. knowlesi

Answer 17

Fy(a-b-)

Question 18

Duffy phenotype that can make anti-Fy5

Answer 18

Fy(a-b-)

Question 19

does Fy(a-b-) phenotype make anti-Fya or anti-Fyb?

Answer 19

no

Question 20

true null Duffy phenotype where Duffy antigens are not expressed on red cells or tissues

Answer 20

FyFy

Question 21

can FyFy phenotype make anti-Fya and anti-Fyb?

Answer 21

yes

Question 22

Fy(a+b-) phenotype frequency

Answer 22

20% white

10% black

Question 23

Fy(a-b+) phenotype frequency

Answer 23

32% white

20% black

Question 24

Fy(a+b+) phenotype frequency

Answer 24

48% white

2% black

Question 25

Fy(a-b-) phenotype frequency

Answer 25

very rare white | 68% black

Question 26

Duffy antibody class

Answer 26

IgG

Question 27

do Duffy antibodies bind complement?

Answer 27

no

Question 28

how much more common is anti-Fya than anti-Fyb?

Answer 28

20x

Question 29

Duffy antibody usually made secondary to other antibodies

Answer 29

anti-Fyb

Question 30

Duffy antibody found only in immunized Fy(a-b-) white individuals

Answer 30

anti-Fy3

Question 31

how to distinguish anti-Fy3 from combination anti-Fya anti-Fyb?

Answer 31

enzymes will not destroy reactions of anti-Fy3

Question 32

Duffy antibody found in blacks with Fy(a-b-) phenotype

Answer 32

anti-Fy5

Question 33

Kidd system gene

Answer 33

JK

Question 34

JK gene located on chromosome ___

Answer 34

18

Question 35

Kidd system antigens located on...

Answer 35

red blood cells and kidney tissue

Question 36

red cell antigens carried by human erythroid urea transport protein HUT11

Answer 36

Jka and Jkb

Question 37

antigens associated with urea transport mechanism

Answer 37

Kidd

Question 38

red cell antigens that reside as antigen clusters on red cell surface

Answer 38

Kidd

Question 39

Kidd antigens on cord cells?

Answer 39

yes

Question 40

effect of enzymes on Kidd antigens

Answer 40

enhanced

Question 41

effect of DTT, AET, chloroquinine diphosphate on Kidd antigens

Answer 41

resistant

Question 42

Jk(a+b-) phenotype frequency

Answer 42

28% white | 57% black

Question 43

Jk(a-b+) phenotype frequency

Answer 43

23% white | 9% black

Question 44

Jk(a+b+) phenotype frequency

Answer 44

49% white | 34% black

Question 45

Jk(a-b-) phenotype frequency

Answer 45

rare in all populations

Question 46

Jka antigen frequency

Answer 46

77% white | 91% black

Question 47

Jkb antigen frequency

Answer 47

73% white | 43% black

Question 48

Jk3 antigen frequency

Answer 48

100%

Question 49

rare homozygous JkJk silent gene phenotype

Answer 49

true null Jk(a-b-)

Question 50

dominant inhibitor suppressor gene Kidd phenotype

Answer 50

In(Jk)

Question 51

test for Jk(a-b-) phenotype

Answer 51

2M urea lysis

Question 52

effect of 2M urea on Jk(a-b-) cells

Answer 52

resist lysis, shrink and shrivel

Question 53

effect of 2M urea on normal Kidd antigen cells

Answer 53

swell and lyse

Question 54

Kidd antibody class

Answer 54

IgG

Question 55

do Kidd antibodies bind complement?

Answer 55

yes

Question 56

IgG antibody that looks like inseparable anti-JkaJkb

Answer 56

anti-Jk3

Question 57

anti-Jk3 reacts with which cells?

Answer 57

all cells except Jk(a-b-)