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CCHS SBB > Blood Components > Flashcards

Blood Components Flashcards

(86 cards)

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1
Q

transport temp of whole blood

A

1-10C

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2
Q

storage temp of whole blood

A

1-6C

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3
Q

expiration of CPDA whole blood

A

35 days

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4
Q

CPDA shelf life

A

35 days

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5
Q

CPDA with additive solution shelf life

A

42 days

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6
Q

open system packed cell expiration

A

24 hours

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7
Q

CPDA unit hematocrit requirement

A

<80%

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8
Q

additive solution unit hematocrit

A

~55-65%

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9
Q

indications for washed packed cells

A

history of allergic trx rxn

IgA deficiency with anti-IgA

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10
Q

washed RBC expiration

A

24 hours

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11
Q

indications for leukocyte reduced RBCs

A

febrile trx rxn due to HLA antibodies
immunosuppressed/immunodeficient
prevent production of HLA antibodies in chronic trx

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12
Q

irradiated RBC shelf life

A

28 days or original shelf life (whichever comes first)

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13
Q

why are irradiated red cells given a shortened expiration date?

A

irradiation weakens RBC membrane, gives unacceptable 24 hour red cell survival after 28 days and increases supernatant potassium

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14
Q

liquid red cell storage temp

A

1-6C

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15
Q

liquid red cell transport temp

A

1-10C

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16
Q

how long after collection are liquid red cells stored?

A

within 24 hours

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17
Q

effects of increased blood storage temperature

A

accelerates metabolism
enzymes become active
bacterial growth

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18
Q

effects of decreased blood storage temp

A

nutrients not utilized
danger of accidental freezing/crystal formation
cells rupture

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19
Q

red cell storage lesion changes

A 
dec plasma pH
dec 2,3-DPG
dec ATP
dec dextrose
dec nitric oxide
inc plasma Hgb
inc plasma potassium
inc plasma ammonia
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20
Q

storage conditions including preservative solutions must provide for survival of red cells so that there are at least ___% viable cells at 24 hours post-transfusion

A

75

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21
Q

storage temp of frozen red cells

A

-80C or lower, -65C max

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22
Q

what cryoprotective agent is used in frozen red cells?

A

glycerol

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23
Q

shelf life of frozen red cells

A

10 years

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24
Q

when after collection can red cells by frozen?

A

within 6 days or after rejuvenation

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25
effect of rejuvenation on red cell units older than 6 days to be frozen
restore 2,3-DPG to near normal | restore ATP to normal or higher
26
shelf life of thawed frozen red cells
24 hours
27
why are red cells from sickle trait donors not frozen?
cannot be deglycerolized, unit forms into gel-mass and hemolyzes during declygerolization
28
indications for frozen/deglycerolized red cells
store blood of donors with rare types store autologous RBCs IgA deficient with anti-IgA severe allergic reactions
29
if declygerolized units are unused, when an they be refrozen?
within 20 hours of original thaw
30
what standard applies to rejuvenation of red cells?
5.7.4.4
31
red cell rejuvenation solution contains?
pyruvate inosine adenine phosphate
32
purpose of red cell rejuvenation
restore 2,3-DPG and ATP levels
33
when can CPD or CPDA-1 red cells be rejuvenated?
after 14 days of liquid storage or up to 3 days past expiration date
34
what can be done to the product after red cell rejuvenation?
washed and transfused within 24 hours | glycerolized and frozen
35
when can AS-1 cells be rejuvenated?
anytime before expiration date
36
frozen storage expiration of rejuvenated, glycerolized AS-1 red cells
3 years
37
whole blood storage temp until platelets are removed
20-24C
38
centrifugation pattern for platelet preparation
light spin --> platelet rich plasma --> heavy spin, remove plasma
39
pH requirement for platelets
>6.2
40
platelet rest time before storage
1 hour
41
minimum platelets per individual donor unit
5.5x10^10
42
platelet expiration if seal broken
4 hours
43
closed platelet pool expiration
5 days
44
open platelet pool expiration
4 hours
45
platelet storage lesion
dec ATP dec ADP dec pH dec platelet glycoprotein
46
composition of fresh frozen plasma
all coagulation factors, including labile V and VIII, antithrombin, ADAMTS13
47
plasma frozen within ___ of whole blood collection
8 hours
48
FFP storage
<18C or colder
49
FFP transport media
dry ice
50
FFP frozen expiration
1 year
51
thawed FF expiration
24 hours (can be 5 days)
52
FFP expiration with broken seal
24 hours
53
what defines 24-hr plasma (PF24)
plasma frozen between 8-24 hours after collection
54
24-hour plasma has reduced levels of?
factor V and VIII
55
single donor plasma (liquid plasma)
plasma that has been separated from whole blood up to 5 days after whole blood expiration date
56
factors present in cryo
fibrinogen VIII vWF XIII
57
main indication for cryo
fibrinogen replacement
58
when is cryo prepared?
anytime during 1 year storage of FFP
59
how is cryo prepared?
FFP placed in 1-6C and allowed to slowly thaw, precipitate forms --> cryo
60
units VIII per cryo bag
80
61
mg fibrinogen per cryo bag
150
62
cryo storage
<18C, optimal -30C or colder
63
frozen cryo expiration
1 year from original whole blood collection date
64
thawed cryo expiration
6 hours
65
thawed cryo storage temp
20-24C
66
open pooled cryo expiration
4 hours
67
indication for cryo-reduced plasma
TTP patients in plasma exchange therapy when non-responsive to albumin or FFP exchanges
68
max red cell loss per week during apheresis
25 mL
69
washed platelet shelf life
4 hours
70
cryoprotective agent in frozen platelets
DMSO (dimethyl sulfoxide)
71
shelf life of frozen platelets
2 years
72
volume reduced platelet shelf life
4 hours (washed)
73
donor Hct requirement for 2-unit red cell apheresis
>40%
74
2-unit red cell apheresis donation interval
16 weeks
75
2-unit red cell apheresis male height/weight requirement
5ft1in | 130 lb
76
2-unit red cell apheresis female donor requirement
5ft5in | 150 lb
77
indication for plasma derived factor VIII
hemophilia A
78
contraindication for recombinant FVIII
von Willebrand's disease
79
indication for factor XI
hemophilia B | hemophilia A with factor VIII inhibitors
80
use of 5% albumin
hypovolemic shock, burn patients, therapeutic apheresis
81
use of 25% albumin
cerebral edema
82
advantage of albumin
remains intravascular, increases colloid osmotic pressure, rapidly expands volume, pulls fluid from interstitium
83
temperature QC required on blood storage devices
must record continuously and be manually checked daily manual reading every 4 hours is not continuous automated check deviations recorded on chart with date and tech ID
84
products transported at 1-10C on wet ice
whole blood red cells thawed or liquid plasma
85
products transported frozen on dry ice
frozen red cells frozen plasma frozen cryo
86
products transported at 20-24C
platelets granulocytes thawed or liquid cryo

CCHS SBB (40 decks)

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