Absorption

Question 1

Absorption

Answer 1

the irreversible movement of a drug into systemic circulation

Question 2

what is bioavailability

Answer 2

the fraction of the drug thats available in blood supply after administration
–> must sit in theraputic window between minimum effective conc and max tolerated conc

Question 3

factors affecting absorption

Answer 3

1. acid stability
2. lipophilicity
3. molecular size

Question 4

1. Transcellular absorption

Answer 4

aka diffusion. must be in solution at cell surface

Question 5

2. Paracellular absorption

Answer 5

pass through the gaps between cells. restricted to low molec. weight, hydrophillic molecules

Question 6

3. Active transport

Answer 6

against conc gradient carried through by transporter (use ATP)