ACE, ARB, DRI, CCB Flashcards
(36 cards)
Which class of antihypertensives cause angioedema and cough
ACE inhibitor
Which two anti hypertensives should not be given after the first trimester of pregnancy due to the risk of renal impairment
ACE and ARB
What level of creatinine should ACE be discontinued?
2.5mg/dL
Which class of anti HTN can lead to anemia and how ?
ACE inhibitors, they decrease erythropoietin
How often should creatinine be checking in patients receiving ACE
3-5 days after starting ACE
What causes the cough associated with ACE
The breakdown of bradykinin
What drug should you change too when patients develop a cough on ACE?
ARB
How should you adjust digoxin dose on patients taking ACE
Decreased dig by 15-30% of the dose
What do ARBs antagonize to cause vasoconstrictive effects?
Angiotensin II
What are the three pro drugs of ARBs?
Candesartan, olmesartan, azilsartan
Which ARB has the highest bioavailability
Irbesartin
Which ARB has the longest half life
Telmisartan
Which med is increased with ARBs
Lithium
What is the benefits of ARBs over ACE
less angioedema and cough
What is the direct renin inhibitor used for HTN
Aliskiren
How long does it take Aliskiren to have the max anti HTN effect
2 weeks
What two classes can you add to Aliskiren ?
TZD diuretics and ARBs especially valsartan
What are the common AE of aliskiren
GI effects that are dose dependent
What patients should not be treated with aliskiren + ACE or ARB
Diabetes, increased the risk of hyperkalmeia
How are CCBs characterized
Non dihdropyridines and dihdropyridines
How do CCB block calcium?
They bind to L type calcium channels in the heart and smooth muscle.
Which class of drugs can cause reflex tachycardia
DHP CCB
T or F CCB causes a change in plasma volume
F they have no diuretic affect
