Anticoags Part 2 Flashcards
How is protamine administered for OD
IV
When is LWMH contraindicated before procedure
Spinal anesthesia or lumbar puncture
What is the indication for LWMH in pregnancy and lactation
Cat b
Caution in lactation
When is fondaparinux indicated
Prevention of DVT in orthopedic patients and DVT or PE. also DVT prophylaxis in patient with HIT
What is the black box warning in fondaparinix
Avoid in spinal anesthesia or lumbar puncture, can cause paralysis
Where should patient be advised to watch for bleeding while taking foondaparinix
Mouth, urine, or stool
What factors do thrombin activate
V, VIII, XI
Which anticoags don’t have a risk for HIT
Direct thrombin inhibitors
What are the three parental DTI
Desirudin, Bivalirudin, and agratroban
What is the oral DTI
Dabigatran
What is desirudin indicated for
DVT prevention in total hip replacement
What is bivalirudin indicated for
Unstable angina undergoing PTCA, risk for HIT undergoing PCI, and use with ASA
What is argatroban indicated in
Prophylaxsis for thrombosis, patients at risk for PCI
What should you consider when prescribing desirudin
Renal impairment less than 60 creatinine clearance
What should you consider when prescribing argatroban
Hepatic impairment
What is the potential antidote to parenteral DTI overdose
Ciraparantag
Which DTI is least safe in pregnancy
Desirudin
Which LWMH drugs is used for long term VTE in cancer patients
Dalteparin
Which DTI is used for HIT induced thrombosis
Argatroban
Is heparin direct or indirect theombin inhibitor LMWH drug
Indirect
