Anticoags Part 1 Flashcards
What mediator cause platelets to aggregate?
TXA 2
What is secondary Hemostasis?
The formation of a fibrin clot via a intrinsic pathway or extrinsic pathway
Which patients are anticoagulated with warfarin
Afib and mechanical heart valves
What are the LMWH drugs
Enoxaparin, dalteparin, tinzaparin
What is the med used for heparin OD
Protamine sulfate
What forms together to form a clot that patches an injured blood cell?
Fibrin and platelet aggregate
What are the three main components of blood clots
Platelets, thrombin, and fibrin
What forms TXA2
Arachidonic acid and COX
What is the extrinsic pathway
Factor VII activated and initiates cascade, it is short than the intrinsic pathway
What factor activates the intrinsic pathway
XII
What results in disorders from the coagulation cascade from extrinsic pathway
Bleeding into cavities and subcutaneous hematomas
What results from primary hemostasis
Mucus bleeding, petechiae
Which disease can result from both pathways?
Von willebrand disease
What is the molecule that inhibits the extrinsic pathway
Tissue factor pathway inhibitor
What does factor X convert to in the extrinsic pathway
Factor II
What is released by the body to dissolute clots
tPA
What can cause prolonged bleeding after minor trauma
Primary platelet plug
CHA2DS2 VASc what falls into 1 pt and 2 point?
1pt- HF, HTN, and ages 65-74 female
2pts- age > 75 history of stroke, TIA, or thromboembolism
What are the direct factor inhibitors
Rivaroxaban, apixaban, edoxaban
What antibody is formed in HIT in response to heparin
IgG
What is most important for monitoring of heparin
aPTT, and Xa and thrombin
What is the therapeutic range of UFH
1.5-2.5 ULN
T or F does heparin degrade clots
F
