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Pharm Test 5 > Antiplatelets And Fibrinolytics > Flashcards

Antiplatelets And Fibrinolytics Flashcards

(53 cards)

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1
Q

What is the ADP Inhibitors

A

Clopidogrel, praugrel, ticagrelor, cangrelor

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2
Q

What are the PDE inhibitors

A

Cilostazol, dipyridamole

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3
Q

What are the protease PAR inhibitor

A

Votapaxar, atopaxar

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4
Q

Glycoprotein antagonists

A

Abciximab, triofiban, eptifibatide

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5
Q

Thromboxane inhibitors

A

Apsirin

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6
Q

What can aspirin be used for

A

Prevention of CVA, CAD, STEMI

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7
Q

What are the AEs of aspirin

A

Gastritis, rhinitis, angioedema, tinnitus, beonchospams

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8
Q

What are the ADP thienopyridines

A

Clopidogrel and prasugrel

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9
Q

What are the ADP non thienopyridines

A

Ticagrelor and cangrelor

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10
Q

What is the standard therapy for acute coronary syndrome

A

Aspirin + clopidogrel

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11
Q

Which ADP is given IV

A

Cangrelor

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12
Q

Which ADP has the longest half life

A

ticagrelor

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13
Q

What are the four main things platelets do

A

Adhere to injured blood vessel, recruit additional platelets, released coag factors, and form aggregates that affect primary hemostasis

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14
Q

What are the glycoprotein antagonists

A

Abciximab, triofiban, and eptifibatide

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15
Q

When agent is indicated in heart valve replacement

A

Dipyridamole

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16
Q

What drug is used for TIA

A

aspirin

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17
Q

What drugs can you combine for PAD

A

Vorapaxar + apsirin or clodpidogrel

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18
Q

Which medication can cause vasovagal hypotension, and thrombocytopenia

A

Tirofiban

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19
Q

What is the PD of apsirin

A

Inhibit COX and TXA2 and platelet aggregation for the lifespan (5-7 days) of the platelet

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20
Q

Above what does of aspirin is patients more at risk for cardiac events

A

325mg

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21
Q

When is apsirin contraindicated

A

Asthma, allergic rhinitis, nasal polyps

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22
Q

When should apsirin be stopped in pregnancy and why?

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A

During the third trimester or close to term because it can cause fetal cardiovascular system problems like closure of the duct arteriosus

23
Q

What is the aspirin hypersensitivity triad risks

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A

Allergic rhinitis, asthma, and nasal polyps

24
Q

How does aspirin affect glucose levels in adults versus children?

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A

It can cause hypoglycemia and children and hyperglycemia and adults

25
What is the allosteric antagonist to ADP
ticagrelor
26
Which is the reversible ADPs
Ticagrelor and cangrelor
27
Which ADP is administered IV
cangelor
28
When is clopidogrel indicated
Acute coronary syndrome NSTEMI, STEMI, or thrombosis prevention
29
How long is the duration of anti platelet therapy of aspirin + P2Y12 for acute coronary syndrome
12 months
30
Which med is a weak anti platelet inhibitor and vasodilator and a PDE3 inhibitor
Dipyridamole and cilostazol
31
How is dipyridamole used after heart valve replacement for prevention of embolism?
In combination with warfarin
32
What is the combination dipyridamole and aspirin called?
Aggrenox
33
What increases the absorption of cilostazol?
Increased with food
34
What is the labeled use of cilostazol
For intermittent claudication caused by peripheral arterial disease and associated thrombosis
35
What is vorapaxar mechanism of action
Protease antagonizer to prevent platelet aggregation
36
What are the three parentally administered glycoprotein targeted agents for acute coronary syndrome?
Abciximab, triofiban, and eptifbatide
37
When are the glycoprotein antagonist indicated?
Only when required for urgency after coronary angiography, and when patients are allergic or can’t tolerate P2Y12 inhibitors
38
Why does Abciximab result in more bleeding complications that other glycoprotein agents?
It prevents both platelet adhesion and aggregation
39
Which glycoprotein antagonist is smaller and a synthetic molecular structure that has a high infinity only for glycoprotein binding sites
Tirofibin
40
What is the goal of the glycoprotein protein antagonist?
To achieve 80% inhibition of platelet aggregation to maximize benefits and minimize adverse effects like bleeding
41
Which GP antagonist has the highest affinity for GP receptors?
Abciximab
42
Which two glycoprotein antagonist have the longer half-life of the class?
Eptifibatide and tirofiban
43
When are most incidents of thrombocytopenia related to GP antagonists occur?
Within 24 hours of the infusion
44
What level of platelets is contraindicated in GP antagonist dosing
Less than 150
45
what is an anti-platelet drug that is a thienopyridine and a vasodilator used to prevent thrombus formation and peripheral artery disease
Cilostazol
46
How do fibrinolytic drugs work?
They activate plasminogen to form plasmin that breaks up fibrin molecules holding clogs together
47
What are the three classes of fibrinolytic drugs
tPA, streptokinase, and urokinase
48
What are the three TPA drugs?
Alteplase, reteplase, tenecteplase
49
What are all three TPA drugs used for?
Acute MI
50
What is the only TPA drug used for severe pulmonary embolism and acute stroke?
Alteplase
51
What is the time limit on using out a place for a thrombotic stroke?
Within 4.5 hours of symptom onset
52
What is the off label use of alteplase
Deep vein thrombosis and peripheral arterial thromboembolism 
53
Who is tPA contraindicated in?
People over the age of 75 years old, diabetic retinopathy pericarditis or pericardial fluid uncontrolled hypertension over 180/110 platelets less than 100 blood glucose less than 50

Pharm Test 5 (20 decks)

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