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Flashcards in ACEI DRUG SPECIFIC Deck (14)
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1

What is the prototype ACEI?

Captopril

2

What is the dose of Captopril?

12.5 to 25mg q 8 hours.

3

Onset of captopril?

15 minutes.

4

E1/2T of captopril?

2 hours.

5

What kind of effect does captopril have?

Decreases SVR, does not affect SNS outflow...

6

What kind of side effects does captopril have?

Rash, loss of taste, antagonizes the effects of NSAIDs, hyperkalemia and angioedema.

7

What is different about Enalapril as compared to captopril?

Enalapril is a pro drug (meaning it has to be metabolized first). Compared to captopril it lacks a sulfhydryl group thus does not cause the rash and renal insuff caused by captopril.

8

How is Enalapril given?

IV

9

What kind of form is lisinopril administered in? And how is it excreted?

Administered in an active form.
Excreted unchanged in the kidney.

10

So which of the ACE inhibitors is a prodrug?

Enalapril.

11

List the three ACEI in order of their onset effect quickest to slowest?

1. Captopril (15-30 minutes)
2. Lisinopril (60 minutes)
3. Enalapril (60-120minutes)

12

List the three ACEI in order of there time of peak action?

1. Captopril (1-2 hours)
2. Lisinopril (2-4 hours)
3. Enalapril (4-8 hours)

13

List the three ACEI in order of there duration of effect?

1. Captopril 6-10 hours
2. Lisinopril 18-30 hours
3. Enalapril 18-30 hours

14

All of the ACEI work more on which the venous or arterial system?

Arterial.