Flashcards in ARBs Deck (8)
What is the site of action of the ARBS?
Angiotension II (AT1) receptors.
What is the MOA of ARBS?
Competitive binding to inhibit the action of angiotension II at it's receptor without affecting ACE activity.
What does the blockade of the Angiotension II (AT1) receptor result in?
Decreased peripheral vasoconstriction and blocked aldosterone secretion.
How do the SE of ARBS compare to ACEI?
They are about the same. A little less cough is noted int the ARBS.
SO then what again are the side effects of ACEI (which can now also be thought as the SE of ARBS?)
Upper respiratory congestion
Do ARBs have an effect on ACE or cause bradykinin accumulation?
When are ARBs contraindicated?
Renal artery stenosis