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Flashcards in ARBs Deck (8)
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1

What is the site of action of the ARBS?

Angiotension II (AT1) receptors.

2

What is the MOA of ARBS?

Competitive binding to inhibit the action of angiotension II at it's receptor without affecting ACE activity.

3

What does the blockade of the Angiotension II (AT1) receptor result in?

Decreased peripheral vasoconstriction and blocked aldosterone secretion.

4

How do the SE of ARBS compare to ACEI?

They are about the same. A little less cough is noted int the ARBS.

5

SO then what again are the side effects of ACEI (which can now also be thought as the SE of ARBS?)

Granulocytopenia
Angioedmema
Proteinuria
Prolonged hypotension
Upper respiratory congestion
rhinorrhea.

6

Do ARBs have an effect on ACE or cause bradykinin accumulation?

NO

7

When are ARBs contraindicated?

Renal artery stenosis
Pregnancy

8

What is common about the ARBs name?

they all end in "sartan" yay!