Flashcards in ARBs Deck (8)
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1
What is the site of action of the ARBS?
Angiotension II (AT1) receptors.
2
What is the MOA of ARBS?
Competitive binding to inhibit the action of angiotension II at it's receptor without affecting ACE activity.
3
What does the blockade of the Angiotension II (AT1) receptor result in?
Decreased peripheral vasoconstriction and blocked aldosterone secretion.
4
How do the SE of ARBS compare to ACEI?
They are about the same. A little less cough is noted int the ARBS.
5
SO then what again are the side effects of ACEI (which can now also be thought as the SE of ARBS?)
Granulocytopenia
Angioedmema
Proteinuria
Prolonged hypotension
Upper respiratory congestion
rhinorrhea.
6
Do ARBs have an effect on ACE or cause bradykinin accumulation?
NO
7
When are ARBs contraindicated?
Renal artery stenosis
Pregnancy
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