Acid-Base- Exam 1 Flashcards Preview

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Flashcards in Acid-Base- Exam 1 Deck (26):
1

Acid

donates a proton

2

Base

can accept a proton

3

pH Equation

ph= -log [H+]

4

What affects dissociation of molecules in solution?

Decreased temperature produces
Decreased energy which produces
Decrease in dissociation which produces
Decrease in concentration of all ionized components

5

pH of Neutrality

At equilibrium, the pH produced by the dissociation of water reaction

6

At 27 degrees C, what is the pH of neutrality?

7.0

7

Henry's Law

Dissolved = Solubility x Partial Pressure

8

Solubility of CO2 @ 37 degrees C

0.06 mls CO2/100 mls bld/mmHg

9

Solubility of O2 @ 37 degrees C

0.003 mls O2/100 mls bld/mmHg

10

How is CO2 moved from the tissue to the lungs?

1. Dissolved
2. Bound to hemoglobin
3. As HCO3-

11

What is the equation for CO2 "content"

Content = Solubility x PP

12

What is the relationships between solubility and temperature?

Solubility is inversely proportional to temperature

13

What are the three ways you can change the pH of blood in a "closed" system?

1. Change total CO2 content; temp constnat
2. Change temperature; keep CO2 constant (change driven by dissociation constant)
3. Change CO2 content AND temperature

14

What will happen to [H+] and pH as you increase temperature?

[H+] will increase
pH will decrease
drives acid-base dissociation equilibrium to the right

15

What will happen to [H+] and pH as you decrease temperature?

[H+] will decrease
pH will increase
drives acid-base dissociation equilibrium to the left

16

Buffer systems are designed to maintain what constant ratio of [OH-] to [H+]?

16:1

17

What three components help maintain buffer systems in the body?

Bicarbonate, protein, phosphate

18

What is the primary blood buffering system response for buffer systems in the body?

Imidazole moiety of the amino acid histidine

19

Where is the imidazole moiety of the amino acid histamine found?

It's found on most blood borne proteins.

20

What accounts for most of the changes in pH due to changes in temperature?

Dissociation of Him+ --> H+ + Im

21

Alpha state and pH stat management ONLY affect control of__________ and __________.

Arterial pCO2
pH

22

What value must always be temperature corrected?

Arterial pO2

23

pH-Stat management

maintain constant pH with change in temperature

24

Alpha-stat management

maintain constant CO2 content with change in temperature

25

pH-Stat Consequences during hypothermia

blood more acidic
hydrogen ion gradient across the cell membrane changes
acidity alters metabolic activity
cells do not maintain electroneutrality
added CO2 influences blood flow regulation

26

Alpha-stat consequences during hypothermia

maintain constant charge on alpha-imidazole side chain
hydrogen ion gradient across cell does not change
cellular enzyme functions are maintained
cells maintain electroneutrality
auto-regulation of blood flow maintained