Flashcards in Blood Surface Interactions (Part 2)- Exam 3 Deck (72)
What are 3 major types of blood cells?
RBCs, WBCs, platelets
What do erythrocytes do?
Uptake, transport, removal oxygen and carbon dioxide
What are two main types of leukocytes?
What are 3 types of granulocytes?
What percent are neutrophils? What do they do?
60-70%; destroy bacterial and phagocytosis
What percent are eosinophils? What do they do?
2-4%; destroy complex products antigen-antibody reactions
WHat percent are basophils? What do they do?
0.5-1%; release histamine and heparin; vasodilation
What are two types of agranulocytes?
What percent are monocytes? What do they do?
3-8%; transform into tissue macrophages
What percent are lymphocytes? What do they do?
20-25%; attach destroy/ deactivate bacteria, viruses, other foreign cells, acquired immune response
What are platelets (thrombocytes) involved in?
What are the 5 major cell types involved in blood surface interactions?
Platelets- Initial/Early Activation
Surface contact with ECC
Heparin (increases sensitivity)
Circulating thrombin (agonist, probably initial activator)
Platelets - Late Activation
Activated Complement (C5b - C9)
Platelets respond to activation with immediate _____.
What shape changes do platelets in response to activation?
Express pseudo pods
Express surface receptors (GP2b/3a and GP1b)
Secrete receptors from granules (P-selectin)
5 actions of platelets responding to activation
1) Immediate shape change
2) GP2b/3a receptors bind to surface adsorbed fibrinogen (use fibrinogen as bridge to bind to other platelets)
3) P-selectin receptors bind to monocytes & neutrophils to form aggregates
4) Some platelets break off forming emboli
5) Some platelets release a variety of chemicals and proteins
Examples of the variety of chemicals and proteins that platelets release in response to activation
platelet factor 4
_____ = very strong activation
Principal agonists of neutrophil
Kallikrein and C5a
Other neutrophil agonists are:
Interleukin 1 Beta
Events in neutrophil activation
*Release contents of granules
*Express MAC-1 (CD11b/CD18) & CD11c/CD18 receptors
*Express L-selectin receptor
Lysosomal enzymes, elastase, myeloperoxidase, hydrogen peroxide, hydroxyl radicals, hypochlorous acid, hypobromous acid, acid hydrolyses, and collagenases are contents released from _____ during neutrophils activation.
What does L-selectin receptor bing with?
P-selectin expressed by endothelial cells and platelets
What plays a major role in ischemia-reperfusion injury and responsible for much of inflammatory response associated with bypass?
Monocyte activation is _____ during CPB.
Monocyte activation is slow activation during CPB by (3):
Monocytes are activated in ____ and ____.
wound and circuit
Monocytes form conjugates with platelets via ____ and express ____.