ACNE treatment

Question 1

1. What acne treatment is a topical combination of adapalene + benzoyl peroxide used for?

Answer 1

Any acne severity

Question 2

1. What are the side effects of adapalene + benzoyl peroxide?

Answer 2

Skin irritation, photosensitivity, bleaching of hair and fabrics

Question 3

1. Is adapalene safe in pregnancy?

Answer 3

No, contraindicated in pregnancy or planning pregnancy

Question 4

1. Does adapalene + benzoyl peroxide contain an antibiotic?

Answer 4

No

Question 5

2. What acne severity treatment combines tretinoin + clindamycin topically?

Answer 5

Any acne severity

Question 6

2. What are the side effects of tretinoin + clindamycin?

Answer 6

Skin irritation, photosensitivity, bleaching of hair and fabrics

Question 7

2. Is tretinoin safe in pregnancy?

Answer 7

No, contraindicated in pregnancy or planning pregnancy

Question 8

2. Does tretinoin + clindamycin contain an antibiotic?

Answer 8

Yes, clindamycin

Question 9

3. What acne treatment is topical benzoyl peroxide + clindamycin used for?

Answer 9

Mild to moderate acne

Question 10

3. What are the side effects of benzoyl peroxide + clindamycin?

Answer 10

Skin irritation, photosensitivity, bleaching of hair and fabrics

Question 11

3. Is benzoyl peroxide + clindamycin safe in pregnancy?

Answer 11

Can be used with caution during pregnancy and breastfeeding

Question 12

3. Does benzoyl peroxide + clindamycin contain an antibiotic?

Answer 12

Yes, clindamycin

Question 14

4. What acne treatment uses adapalene + benzoyl peroxide + oral tetracyclines?

Answer 14

Moderate to severe acne

Question 15

4. What are the benefits of adding oral antibiotics to topical treatment?

Answer 15

Helps reach difficult areas; systemic action

Question 16

4. What are the side effects of this combo (topical + oral)?

Answer 16

Topical: irritation, photosensitivity, bleaching; Oral: resistance risk, systemic side effects

Question 17

4. Are oral tetracyclines safe in pregnancy?

Answer 17

No, they may stain teeth and affect fetal skeletal development

Question 18

5. What acne treatment uses azelaic acid + oral tetracyclines?

Answer 18

Moderate to severe acne

Question 19

5. What are the benefits of azelaic acid + oral antibiotics?

Answer 19

Useful for difficult areas; systemic antibiotic coverage

Question 20

5. What are the risks of using oral tetracyclines?

Answer 20

Photosensitivity, resistance, fetal bone/teeth risks

Question 21

5. Is azelaic acid safer in pregnancy than retinoids?

Answer 21

Yes

Question 22

What is the mechanism of benzoyl peroxide?

Answer 22

Antiseptic, anti-inflammatory, reduces keratinisation; penetrates duct and releases oxygen radicals

Question 23

What is the mechanism of retinoids (adapalene, tretinoin)?

Answer 23

Anti-inflammatory; normalize keratinocyte growth; prevent microcomedones

Question 24

What is the mechanism of azelaic acid?

Answer 24

Anti-inflammatory; normalizes follicular keratinisation; reduces comedogenesis

Question 25

What is the mechanism of tetracyclines/clindamycin?

Answer 25

Inhibit bacterial protein synthesis

Question 26

Overall goal MOA of acne treatment

Answer 26

anti inflammatory, reduce keratinization of skin

Question 27

Concern w/ oral tetracyclines

Answer 27

tetracyclines such as doxycycline and lymecycline can cause photosensitivity and should not be used in pregnancy as can cause discoloration of the child’s teeth and affect skeletal development.

Question 28

Acne formation mechanism

Answer 28

4 main events: Excessive sebum production secondary to stimulation by androgens Abnormal follicular keratinization and desquamation resulting in formation of a follicular plug. Proliferation of the anaerobe Gram positive bacteria Cutibacterium acnes Inflammation.

Question 29

Concern for treatment with Isotretinoin

Answer 29

Isotretinoin- high risk of serious congenital malformations, and any use in females must be within the conditions of the Pregnancy Prevention Programme (usually IUD/implant) and initiated by a dermatologist.