ACTINOBACILLUS Flashcards
(34 cards)
ACTINOBACILLUS PLEUROPNEUMONIAE
VERY IMPORTANT IN SWINE REARING
WORLDWIDE DISTRIBUTION
PIGS <6 MONTHS
HOST SPECIFIC
TWO TYPES OF A. PLEUROPNEUMONIAE
BIOTYPE 1 NAD DEPENDENT
BIOTYPE 2 NAD INDEPENDENT
16 SEROTYPES - GEOGRAPHIC DIFFERENCES, VARYING VIRULENCE
HOW IS A PLEUROPNEUMONIA TRANSMITTED ?
DIRECT PIG TO PIG - AEROSOL
SPREAD THROUGH STABLE PEN TO PEN VIA VENTILATION
REGROUPING OF PIGS
WHERE IS A. PLEUROPNEUMONIAE COMMENSAL
NOSE AND TONSILS
LUNG NODULES OF RECOVERED PIGS
WHAT ARE THE PREDISPOSING FACTORS FOR A PLEUROPNEUMONIAE
VIRULENCE, STRESS, PEN CHANGES, CLIMATE, AIRLFLOW, OVERPOPULATION
WHERE DOES A PLEUROPNEUMONIAE EFFECT
TERMINAL BRONCHI AND ALVEOLI
VIRULENCE FACTORS OF A PLEUROPNEUMONIAE
ADHESION-FIMBRIAE
MULTIPLICATION NEEDS FE- TRANSFERRIN BINDING PROTEINS, HEMOGLOBIN BINDING PROTEINS
EXOTOXINS- APX TOXINS MAKE PORES IN RED BLOOD CELLS, ENDOTHELIUM, NEUTROPHILS, AND MACROPHAGES (O2 RADICALS AND LYTIC)
CAPSULE(EVASION OF HOST IMMUNITY)
LPS (LIPID A ENDOTOXINS)
OUTER MEMBRNE PROTEINS
ENZYMES AND PROTEASES
HEAT SHOCK PROTEINS
EXOTOXINS OF A. PLEUROPNEUMONIAE
I- STRONG HEMOLYTIC AND CYTOLYTIC
II- WEAK HEMOLYTIC AND CYTOLYTIC
III- STRONG CYTOLYTIC
IV- NECESSARY FOR VIRULENCE IN ALL SPECIES
SYMPTOMS OF A. PLEUROPNEUMONIAE
HYPERACUTE- HIGH INFECTION DOSE, DEATH WITHIN HOURS
ACUTE
CHRONIC- STUNTED GROWTH, LUNG DAMAGE, ADHESIVE PLEURITIS, RESPIRATORY DISTRESS, OPEN MOUTH BREATHING, FEVER, ANOREXIA, HEMORRHAGIC NECROTIZING PNEUMONIA
DIAGNOSIS OF A PLEUROPNEUMONIAE
SYMPTOMS, AUTOPSY, BACTERIAL CULTURE- REQUIRES NAD STAPHYLOCOCCUS, CO2 ENRICHMENT, SLOW GROWER
SEROLOGY AT FARM LEVEL
DETECTION OF CARRIERS- PCR SAMPLES FROM NOSE AND TONSILS
TREATMENT AND PREVENTION A. PLEUROPNEUMONIAE
HYGIENE, ABX PARENTERAL (INJECTION) IF SICK, IF NOT YET SICK PER OS
LITTLE ACQUIRED RESISTANCE TO ABX
VACCINE FOR A. PLEUROPNEUMONIAE SHOULD INCLUDE
APX TOXIN, TRANSFERRIN BINDING PROTEIN, TYPE 4 FIMBRIAE
ACTINOBACILLUS SUIS
OBLIGATE SYMBIOTIC- VAGINA AND TONSILS
FACULTATIVE PATHOGENIC
ACTINOBACILLUS SUIS VIRULENCE
APX TOXINS SIMILAR TO TYPE I AND II IN A. PLEUROPNEUMONIAE CYTOLYTIC AND HEMOLYTIC
WHAT IS A SIGN THAT ACTINOBACILLUS SUIS IS ON YOUR FARM?
DEAD MICE
WHERE IS A. SUIS FOUND IN HEALTHY ANIMALS
VAGINA AND TONSILS
A SUIS IN YOUNG PIGS
ACUTE MORTALITY, CLINICAL SYMPTOMS SIMILAR TO A PLEUROPNEUMONIAE
A SUIS IN OLDER PIGLETS
FEVER, ANOREXIA, RESPIRATORY DISTRESS, POLYARTHRITIS
A SUIS IN ADULT PIGS
SUBCUTANEOUS ABSCESSES, ANOREXIA, FEVER, MENINGITIS POSSIBLE
DIAGNOSIS AND TREATMENT
CULTURE AND ABX (LITTLE RESISTANCE)
ACTINOBACILLUS EQUULI TWO SUBSPECIES
SUBSPECIES HAEMOLYTICUS RESERVOIR= HORSE
SUBSPECIES EQUULI RESERVOIR= HORSE AND PIGS
ACTINOBACILLUS EQUULI
OBLIGATE SYMBIOTIC, FACULTATIVE PATHOGENIC
A. EQUULI CAUSES
RESPIRATORY DISTRESS
BRONCHITIS, PLEURITIS, PNEUMONIA
A. EQUULI IN FOALS
SLEEP FOAL DISEASE
ENTERITIS, SEPTICAEMIAE, SLIMY PUS
PREVENT WITH COLOSTRUM
HARD TO TREAT ABX USUALLY FAIL
