Action Flashcards
(36 cards)
Adrenaline : Action
Stimulates ALPHA, BETA receptors of sympathetic nervous system
- ALPHA : peripheral vasoconstriction,
[+]perfusion pressure to vital organs during cardiac arrest
[-]capillary permeability
[+]BP in anaphylaxis - BETA1 : [+]myocardial excitability & contractility, tachycardia
- BETA2: bronchodilation
Amiodarone : Action
slows sinus rate
incr refractory period of AV node
decr peripheral vascular resistance
Aspirin : Action
Inhibits platelet aggregation - limits thrombus enlargement in acute ACS
Reduces production of prostaglandins relieving pain and fever
Atropine : Action
Antagonises parasympathetic effects of acetylcholine on muscarinic receptors:
[+] HR via [+] intrinsic rate of sino-atrial node and conduction through AV node
[-] smooth muscle contraction resulting in pupillary dilation, [-] GIT motility, [-] bladder tone
blocks exocrine gland activity causing [-] salivary, bronchial, gastric and sweat secretions
Benzyl Penicillin : Action
Bactericidal: inhibits bacterial cell wall synthesis and causes cytolysis when the bacterium tries to divide
Calcium Gluconate : Action
Antagonises the effect of hyperkalaemia on the heart.
Clopidogrel : Action
- Specific and potent inhibitor of platelet aggregation and limits propagation of the thrombus by selectively inhibiting the binding of ADP to its platelet receptor.
- Absorbed from stomach and upper bowel. Begins to inhibit platelet function within 30min.
Compound Sodium Lactate : Action
- Distributed throughout extracellular fluid space following IV infusion.
- ~25% remains in intravascular space for a variable period of time.
Droperidol : Action
- Marked tranquilisation and sedation
- [-] BP due to direct vasodilatory effect and ALPHA block.
- Potentiates other CNS depressants: Narcotic analgesics (e.g. Fentanyl) and Benzodiazepines (e.g. Midazolam)
Enoxaparin Sodium : Action
- Induces sustained release of Tissue Factor pathway inhibitor.
- Inhibits Thrombin generation
- Inhibits coagulation factors Xa and Thrombin (anticoagulant)
- {-} reinfarction and ischaemia complications after lysis of STEMI.
Fentanyl : Action
- Potent Analgesic
2. Effective for IN use because it is rapidly absorbed across mucous membranes.
Fexofenadine : Action
Non sedating anti-histamine
Frusemide : Action
Potent loop diuretic which produces [+] urine output by inhibiting renal sodium reabsorption.
Glucagon : Action
Converts liver glycogen to glucose. May not be effective if glycogen is depleted due to starvation or chronic liver disease.
Glucose 10% : Action
Principle energy source for body cells especially brain.
Glucose Gel : Action
Principle energy source for body cells especially brain.
Glyceryl Trinitrate : Action
- Dilates coronary arteries
- Dilates systemic veins and arteries
- Decreases preload, afterload and BP
Hydrocortisone : Action
Glucocorticoid drugs that [-] inflmmation and suppresses immune response.
Ibuprofen : Action
- Inhibition of prostaglandin synthesis which is important in the mediation of pain, fever and inflammation
- Anti-inflammatory and analgesic effects well suited to musculoskeletal injuries
Influenza Vaccine : Action
Induces antibodies against the surface antigens of the influenza virus
Ipratropium Bromide : Action
- (Synthetic derivative of Atropine) mAChR antagonist : blocks vagal reflexes mediating broncho-constriction -> Bronchodilator
- Synergistic with Salbutamol
Ketamine : Action
- Dissociates CNS from painful stimuli.
- Low doses cause a trance-like state characterised by analgesia and amnesia with retention of proactive airway reflexes, spontaneous respirations and cardiovascular activity.
Lignocaine : Action
Blocks fast sodium channels [-] ventricular excitability and pain transmission
Methoxyflurane : Action
CNS depressant
