Flashcards in Acute And Chronic Inflammation Deck (18)
Margination molecules involves?
Rolling molecules involves?
1. P selectins
2. E selectins
1. P selectins histamine IL-1 TNF
2. E selectins IL-1 TNF
Upregulation of integrins
1. On leukocyte
2. On endothelial cells (ICAM and VCAM)
1. C5a, LTB4
2. TNF IL1
Molecules invovled in chemotaxis? (X3)
Molecules in Diapedisis?
Molecules in the downregulation of inflammation?
2. TGF Beta
Most abundant component of the complement system?
C3 which gives rise to
C3a - anaphylatoxin
C3b - opsonin
Hereditary angioedema is caused by?
C1 inhibitor defiency
Paroxysmal nocturnal hemoglobinuria is caused by?
DAF + CD59 deficiency
Susceptibility Neisseria infection
Defects in late components
Hallmark of acute inflammation
1. Leukocytes + fluid
2. Vasodilation of small vessels
Morphological characteristics of chronic inflammation
1. Lymphocytes, plasma cells, monocytes
2. Tissue destruction
3. Attempts at repair (angiogenesis, fibrosis)
Labile tissues can undergo REGENERATION because?
The presence of epithelium and stem cells
Stable tissue can undergo REGENERATION because of the presence of?
Cells in teh G0 phase
5. Smooth muscle, fibroblasts.
Permanent tissue cannot undergo regeneration, instead connective tissue deposition occurs due to?
Tissue is terminally differentiated already.
The most important cytokine in scar formation?