Acute And Chronic Inflammation Flashcards Preview

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Flashcards in Acute And Chronic Inflammation Deck (18)
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1

Margination molecules involves?

selectins

2

Rolling molecules involves?

Integrins

3

Upregulation of

1. P selectins
2. E selectins

1. P selectins histamine IL-1 TNF
2. E selectins IL-1 TNF

4

Upregulation of integrins
1. On leukocyte
2. On endothelial cells (ICAM and VCAM)

1. C5a, LTB4
2. TNF IL1

5

Molecules invovled in chemotaxis? (X3)

1. IL8
2. LTB4
3. C5a

6

Molecules in Diapedisis?

PECAM-1 CD31

7

Molecules in the downregulation of inflammation?

1. IL10
2. TGF Beta
3. Lipoxin

8

Most abundant component of the complement system?

C3 which gives rise to

C3a - anaphylatoxin
C3b - opsonin

9

Hereditary angioedema is caused by?

C1 inhibitor defiency

10

Paroxysmal nocturnal hemoglobinuria is caused by?

DAF + CD59 deficiency

11

Susceptibility Neisseria infection

Defects in late components

12

Hallmark of acute inflammation

1. Leukocytes + fluid
2. Vasodilation of small vessels

13

Morphological characteristics of chronic inflammation

1. Lymphocytes, plasma cells, monocytes
2. Tissue destruction
3. Attempts at repair (angiogenesis, fibrosis)

14

Labile tissues can undergo REGENERATION because?

The presence of epithelium and stem cells

15

Stable tissue can undergo REGENERATION because of the presence of?

Cells in teh G0 phase

Examples
1. Liver
2. Kidney
3. Pancreas
4. Endothelium.
5. Smooth muscle, fibroblasts.

16

Permanent tissue cannot undergo regeneration, instead connective tissue deposition occurs due to?

Tissue is terminally differentiated already.

17

The most important cytokine in scar formation?

TGF beta

18

Granulation tissue the HALLMARK of repair is seen on average in around how many days?

3-5 days