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Flashcards in Wbc Lymph Node Spleen Deck (22)
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1

Most common leukemia of western adults

CLL SLL

2

Most common indolent lymphoma

Follocular lymphoma

3

Most common lymphoma of adults most common NHL

Diffuse large b cell lymphoma

4

Fastest growing human tumor

Marker

Burkitts lumphoma ki 67

5

B cell acute lymphoblastic leukemia mutation

T cell acute lymphoblastic lymphoma mutation

Immunohisto stain

BALL : t(12:21) ETV6 RUNx gene

TALL : NOTCH1 gene

Tdt + MPO-

6

Chronic Lymphocytic leukemia

Mutation

Pathog

Deletion 13, 11, 17, Trisomny 12

Proliferation centers

7

Follicular lymphoma

Mutation

Pathog

BCL2 gene t (14:18)

Centrocytes
Centroblasts

8

Diffuse large b cell lymphoma

Mutation (3)

Common clinical finding

BCL6 gene 3q27

BCL2 gene t(14;18)

MYC gene on chromosome 8

Rapidly enlarging LN and spleen

9

Burkitt lymphoma

Mutation which allows ______

Pathogn

Which type is EBV 100%

MYC gene on chromosome 8, warburg effect

Starry sky: stars macrophage, sky apoptotic b cells

Endemic

10

Mantle cell lymphoma

Mutation

Clinically similar to _a_ and _b_ due to ________

Differentiate mantle cell lymphoma and a and b with pathogn.

IgH locus t (11:14)

Chronic lymphocytic leukemia and follicular lymphoma, generalized lymphadenopathy

NO proliferation centers, no centroblasts respectively

11

Marginal Cell lymphoma

Patho of EXTRA NODAL

Mutation

Chronic inflammation secondary to
Ss, hashimoto, H. Pylori

BCL10,

12

Hairy Cell Leukemia

Where are hairy cells seen?

Red pulp of spleen "splenic sequestration"

13

Anaplastic large cell lymphoma

Mutation

Pathogn.

Location

ALK1 gene on 2p23

Hallmark cell

Lymphoid sinuses (Like mets)

14

Adult T cell lymphoma

Pathogenesis

Pathogn.

Vs Multiple myeloma

Cd+4 infected by Human t cell leukemia virus type 1 = nfkb 1

Cloverleaf / flower cells

Both can have lytic lesions and hypercalcemia but this has skin lesions

15

Mycosis fungoides, sezary syndrome

Pathology

Pathogn.

Mycosis vs sezary.

CD+4 cells of SKIN

Butt / cerebriform nuclei

Exfoilative erythroderma

16

Hodgkin lymphoma

Pathology seen in?

Immuno stain

Axial LN

Cd15, CD30

17

Hodgkin lymphoma

ann arbor I,II most common type and RS cell

Clinical

Associated with what virus??

Nodular sclerosis : lacunar cell + fibrous bands

Lymphocyte predominant : popcorn cell

Mediastinal involvement

No EBV

18

Hodgkin lymphoma

Ann arbor III, IV usual type and RS type

Associated with what virus?

Mixed cellular : mononuclear, with many cells in background

Lymphocyte depleted : mononuclear no lymphocytes

EBV LD > MC

19

Acute myeloid leukemia

Most common mutation

Best prognosis mutation (name)

Worst prognosis mutation, WHO class

t(8:21) RUNx1

t(15;17) FABm3, retinal receptor acute promyelogenous leukemia

Therapy associated leukemia, WHO class III chromosome 5,7 deletion

20

Acute myeloid leukemia

Pathogn. Cell of t(______) mutation

Faggot cells, with auer rods t(15;17)

21

Chronic myelogenous leukemia

Mutation

Mutation also seen in ______

T(9;22) BCR ABL
Philadelphia chromosome

Acute lymphoblastic leukemia

22

Most common cancer of children

Acute lymphoblastic leukemia