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Flashcards in Neoplasia Deck (39)
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1

Hamartoma

Disordered cells of the same organ

2

Choristoma

Organized cells of another organ

3

Hallmark of malignancy?

Anaplasia

4

Morphology of anaplasia

1. Pleomorphism
2. Nuclear morphology
3. Mitoses
4. Loss of polarity
5. Necrosis

1. Variable cell sizes
2. Increased nuclear to cytoplasm ratio
3. Mitotic figures
4. Disordered cells
5. Lack of blood supply

5

The frequent second hit of RB is?

E7 protein of HPV

6

The frequent second hit of p53 is?

E6 protein of HPV

7

Multiple primary tumors will raise suspicion of?

Li fraumeni syndrome: P53 mutations

8

Invasion of apoptosis is usually via the ________ pathway?

Intrinsic pathway or mitochondrial pathway

9

Warburg metabolism is AEROBIC glycolysis; it is peculiar because?

More carbon moieties than ATP are produced vs oxidative phosphorylation.

10

Hypoxia induces angiogenesis in the following 3 oncogenes encoding signal pathways.

RAS
MYC
MAPK

11

The ability of cancer cells to metastasize 4 steps?

1. Loss of E cadherin
2. BM and ECM degradation by proteases
3. Migration

12

Ability to evade host responses of cancer cells is due to

1. Antigen negative cells
2. Less MHC I on cells
3. Immunosupression

13

SquaCA infection

HPV 16,18, 31,33

14

Cholangiocarcinoma, infection

Clonorchis sienesis
Opistorchis viverrini

15

GALT lymphoma, gastric AdenoCA

Helicobacter pylori

16

Hepatocellular CA

Hep B, Hep C

17

Burkitt lymphoma, B cell NHL

EBV

18

Kaposi sarcoma

HHV 8

19

Priamry CNS lymphoma

HIV

20

Bladder SCCA

Schistosoma haematobium

21

Alcohol causes

HCC

22

Arsenic causes

Skin SCCA
Liver angiosarcoma

23

Benzene causes

AML

24

Nitrosamine

Esophagus, stomach

25

Cadimium

Prostate

26

Anilline

Urothelial carcinoma

27

Vinyl chloride

Liver angiosarcoma

28

Radiation

Skin SCCA
Melanoma

29

Sjogren syndrome and hashimoto thyroiditis cuases

MALT lymphoma

30

Causes cancer cachexia

TNF alpha
Proteolysis inducing factor