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Pathology Review COPY > Cellular Adaptation > Flashcards

Flashcards in Cellular Adaptation Deck (11)
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1

2 hallmarks of irreversible cell injury

1. Membrane destruction
2. Mitochondrial damage (no ETC)

2

Necrosis:
1. Pyknosis
2. Karyolysis
3. Karyhorrhexis

1. Nuclear shrinkage (because a small basophilic mass)
2. Decreased basophilia of chromatin (loss of DNA)
3. Fragmentation of nucleus

3

What leaks out of the mitochondrial membrane causing apoptosis for both intrinsic and extrinsic pathways?

Cytochrome c

4

Common apoptosis pathway

1. Pro apoptotic proteins
2. Anti apoptotic proteins

1. BAX-BAK
2. BCL2

5

Intrinsic apoptotic pathway caspace

Caspace 9

6

Extrinsic apoptitic pathway caspace

Caspace 8
Caspace 10 (human)

7

Necroptosis is caspace independent; is activates what complexes?

1. RIP 1 and RIP 3

8

Russell bodies are seen in what cells?

Plasma cells producing excessive Immunoglobulins

9

Lipofuschin is the wear and tear pigment; it is a sign of?

Free radical injury: (lipids inside complex)

10

What substance is black in urine of alkaptonuria?

Homogentisic acid (ochronosis)

11

Nutrient deficiency increases longevity by?

Decreasing IGF/insulin signaling leading to INCREASED sirtuins