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Flashcards in Adrenergics Deck (63):
1

blocks L-type calcium channels at higher doses

carvedilol

1

what receptors does labetalol affect?

α1 and β1/2

1

which adrenergic neuron blocker can enter the CNS?

guanadrel

2

therapeutic use of carvedilol

  • hypertension
  • chronic heart failure
  • acute MI

3

which therapeutic use of propranolol is not shared by atenolol?

migraine prophylaxis

3

what does reserpine treat?

essential HTN, rarely used

4

decreases vascular tone in resistance (arterioles) and capacitance (veins) beds

prazosin

5

how is phentolamine administered?

orally

7

competitive antagonist of α1 and both β receptors

labetalol

carvedilol

8

what receptors does timolol affect?

non-selective β antagonist

8

this β1 antagonist does not penetrate the CNS, so it has less CNS side effects

atenolol

8

this α1 receptor antagonist is not approved for threatment of HTN

tamsulosin

8

how is prazosin administered?

orally

9

what receptors does phenoxybenazmine affect?

irreversible α1 and α2 antagonist

10

therapeutic use of labetalol

  • essential hypertension (oral)
  • hypertensive emergencies (IV)

11

orally active α1 recepotr antagonist with some selectivity for α1A verses α1B subtypes

tamsulosin

12

what is tamsulosin used to treat?

BPH with little effect on blood pressure (less propensity for orthostatic hyptotension)

12

adrenergic neuron blockers

guanethidine

guanadrel

inhibit NE release by taking its place in vesicles

13

produces a favorable lipid profile by decreasing LDL and increases HDL

prazosin

13

what drug causes first dose phenomenon?

prazosin

14

clinical uses of phenoxybenzamine

  • pheochromocytoma
  • reverse or shorten duration of soft-tissue anesthesia

15

what receptors does tamsulosin affect?

α1 (mostly α1A) antagonist

17

what receptors does metoprolol affect?

β1 antagonist

18

at low doses is more selective at blocking the β1 receptor by 10-fold

metoprolol

19

how is tamsulosin administered?

orally

20

prwhat receptors dose prazosin affect?

α1 antagonist

21

describe propanolol's withdrawal syndrome

supersensitivity to β adrenergic stimulation which may cause angina, arrhythmias, or infarction

23

what receptors does atenolol affect?

β1 antagonist

24

also has anti-oxidant properties and anti-inflammatory effects

carvedilol

25

therapeutic use:

  • essential hypertension (oral)
  • hypertensive emergencies (IV)

labetalol

25

clinical uses of phentolamine

  • HTN
  • pheochromocytoma
  • reverse or shorten duration of soft-tissue anesthesia

26

which drugs reverse or short the duration of soft-tissue anesthesia produced by combined local anesthetic and sympathomimetics?

phentolamine

phenoxybenzamine

28

which drug masks the symptoms of hypoglycemia?

propranolol (and related drugs)

29

treats shock

NE

DA

phenylephrine

31

which drug can cause sedation, impotence, and nightmares?

propranolol

32

what drugs share therapeutic uses with propranolol?

atenolol

metoprolol

timolol

34

orally active, once a day dosing

atenolol

35

37

how is atenolol administered?

orally active, once a day dosing

39

β1 receptor antagonists

metoprolol

atenolol

40

what is distinct about timolol?

treats wide angle glaucoma

41

which of the 2 β blockers that we need to know treat heart failure?

metoprolol

carvedilol

42

what receptors does phentolamine affect?

α1 and α2 antagonist

43

therapeutic use:

  • chronic heart failure
  • hypertension
  • acute MI

carvedilol

44

what do guanethidine and guanadrel treat?

hypertension (limited use)

44

orally active pro-drug

methyldopa

46

how is phenoxybenzamine administered?

orally

47

how are guanethidine and guanadrel administered?

orally

48

side effects of phentolamine and phenoxybenzamine?

  • tachycardia
  • edema (salt/water retention)
  • orthostatic hypotension

49

side effects of propranolol

  • cardiac depression, bradycardia/heart block
  • may increase airway resistance
  • mask symptoms of hypoglycemia
  • sedation, impotence, nightmares

50

how is labetalol administered?

orally (HTN) & IV (HTN emergencies)

50

used with local anesthetics to increase duration of action

phenylephrine

epinephrine

51

used in emergencies to stimulate heart rate during bradycardia or heart block

isoproterenol

52

major therapeutic uses of propranolol

  • HTN
  • angina
  • cardiac arrhythmias due to excess catecholamines
  • acute MI
  • pheochromocytoma
  • migraine prophylaxis

54

how is resperine administered?

orally

55

why is reflex achycardia less problematic in prazosin usage?

little blockage of pre-synaptic α2 receptors - minimal increase in CO

56

what receptors does carvedilol affect?

α1 and β1/2

57

which adrenergic neuron blocker is polar and cannot enter the CNS?

guanethidine

59

this drug enters the CNS and may cause depression, suicide, sedation

reserpine

60

favors blockade of α1A in prostate

tamsulosin

61

what receptors does propranolol affect?

non-selective β antagonist

62

propranolol should be used with caution with what kinds of patients?

  • asthma
  • congestive heart failure
  • bradyarrhythmias, AV block
  • insulin-dependent diabetes prone to hypoglycermic episodes
  • hypotension
  • vasospastic angina

63

how is phenylephrine administered?

nasal spray or orally

ophathalmic