Pharmacology of Inflammation Flashcards Preview

Pharmacology > Pharmacology of Inflammation > Flashcards

Flashcards in Pharmacology of Inflammation Deck (44):
1

increase vascular permeability, bronchoconstriction

leukotrienes

1

prostaglandins class

lipid mediators

2

increased extracellularly during injury: anti-inflammatory, inhibit cytokine action

adenosine

2

glucocorticoids cellular source

adrenal cortex

3

bradykinin cellular source

endothelial cells

4

bradykinin class

peptide

4

Oxygen-derived free radicals class

superoxide, hydroxy radicals

5

vasodilation, pain, fever, platelet aggregation (via thromboxane)

prostaglandins

5

cell adhesion molecules mechanism

contact molecules, calcium dependent

6

prostaglandins mechanism

activation of specific GPCRs

7

adenosine cellular source

all cells

7

leukotrienes mechanism

activation of GPCRs

8

glucocorticoids class

lipid mediators

9

prostaglandins cellular source

virtually all cells

10

complement system cellular source

synthesized by liver, circulate in blood

11

C-reactive protein class

plasma proteins

12

Histamine cellular source

mast cells, basophils

13

complement system mechanism

complement protein complexes cause osmotic lysis activation of GPCRs

14

C-reactive protein cellular source

produced in liver in response to cytokines, also produced in adipocytes

15

cell adhesion molecules cellular source

endothelial cells, platelets, leukocytes

16

leukotrienes cellular source

macrophages, neutrophils

17

cytokines mechanism

bind to specific receptor proteins to induce gene expression of number of proteins via activation of Nf?B and AP-1; increase COX (fever) and lipoxygenases, increase adhesion molecule expression, induce collagenase (fibrosis)

19

inhibition of cytokines, inhibition of phospholipase A2, inhibition of COX-2, inhibition of cell adhesion molecules

glucocorticoids

21

vasodilation, increased vascular permeability, pain

histamine

22

cytokines class

secreted proteins, in particular the pro-inflammatory cytokines: Interleukin-1 (IL-? & IL-?) and TNF-?

24

vasodilation, increased microvessel permeability, pain

bradykinin

25

cell adhesion molecules class

family of proteins

26

histamine class

biogenic amine

27

Acute-phase reactant, activates complement cascade, mediates phagocytosis, marker of inflammation

C-reactive protein

28

Histamine mechanism

activation of GPCRs

29

adenosine mechanism

activation of GPCRs

31

cytokines cellular source

nearly all inflammatory cells

32

glucocorticoids mechanism

activation of nuclear receptors

33

intracellular killing of bacteria by neutrophils

Oxygen-derived free radicals

34

chemotaxis, promote release of mediators from neutrophil, increase vascular permeability, excessive activation may contribute to tissue injury

complement system

35

Oxygen-derived free radicals cellular source

all cells

36

Oxygen-derived free radicals mechanism

protein oxidation, lipid peroxidation, DNA mutations

37

leukocyte adhesion to endothelium is a pivotal event in host defense and tissue repair, endothelial adhesion molecules contribute to recruitment of activated platelets

cell adhesion molecules

38

bradykinin mechanism

activation of GPCRs

40

TNF-?: acute phase reaction, fever, sepsis; IL-1: acute phase reaction, fibroblast, and lymphocyte proliferation, fever

cytokines

41

leukotrienes class

lipid mediators

42

adenosine class

purine nucleoside formed from breakdown of ATP

43

complement system class

plasma proteins

44

C-reactive protein mechanism

bind to phospholipids in bacteria and damaged cells may be specific receptors in macrophages