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Flashcards in Pharmacokinetics Deck (16):
1

Bioavailability

(F), fraction of the dose that reaches the systemic circulation
F = amount in the circulation/total amount administered

2

First pass effect

Drugs pass through the liver where metabolism can occur. the more metabolism, the more bioavailability is reduced

3

Bioequivalence

two drug preparations with the same active ingredients at the same amount and delivered by the same route of administration and the extent and rate of drug delivery to the circulation are the same

4

Redistribtion

Drug being delivered to other organs from its site of action

5

Therapeutic window

Concentration of a drug in the body that is high enough to produce the desired effect with a minimum of toxicity

6

Volume of distribution

A measure of the apparent space in the body available to contain the drug, based upon the assumption that the concentration of drug throughout the body is the same as its concentration in the plasma

7

Clearance

rate of elimination/concentration, units are liter/min

8

Rate of elimination

the rate a drug is eliminated from the body...

9

Half-life

the time it takes for half the quantity of a first order drug to be eliminated

10

Loading dose

a big initial dose

11

Maintenance dose

a regular dose to keep concentrations in the therapeutic window

12

Major carrier for acidic drugs

Albumin, decreased by severe liver disease

13

Major carrier for basic drugs

Alpha1-acid glycoprotein, increased by immune activation (Crohn's disease)

14

Organic-anion transporting polypeptide (OATP)

Remove the drug from the endothelial cell back into the blood

15

P-glycoprotein

Remove the drug from the endothelial cell back into the blood

16

Transport proteins in the proximal tubule that can move drugs against their concentration gradients into the lumen

P-glycoprotein, MRP2 (multidrug-resistance-associated protein type 2)