Neuropsychopharmacology Flashcards Preview

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Flashcards in Neuropsychopharmacology Deck (13):
1

Dopamine pathways in the brain include:

  1. Nigrostriatal
  2. Tubero-infundibular
  3. Mesolimbic
  4. Mesocortical

2

GABA localization:

  1. Substantia nigra
  2. Globus pallidus
  3. Hippocampus
  4. Limbic structures
    • Amygdala
    • Hypothalamus
    • Spinal cord

3

Half life of duloxetine

12-18 h

4

Use with caution in pt's with liver disease

Approved for use in fibromyalgia, diabetic neuropathy, back pain, and osteoarthritis pain

duloxetine

5

blocks norepinephrine and dopamine uptake

bupropion

6

plasma half life of tricyclic antidepressants

8-100 hours

7

drug interactions of tricyclic antidepressants

guanethidine - blocks guanethidine uptake

sympathomimetic drugs - particularly indirect acting ones

effects on absorption and metabolism of other drugs

8

causes enuresis

tricyclic antidepressants

9

which drugs interact with tyramine from food to produce hypertensive effects?

MAO inhibitors

10

may progress to hypomania, particularly in bipolar disease

MAO inhibitors

11

dopamine receptors that activate adenylyl cyclase

D1 type (D1 and D5)

12

dopamine receptors that inhibit andenylyl cyclase

D2 type (D2, D3, D4)

13