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Flashcards in Adverse effects Deck (43)
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1

Lower seizure threshold

Bupropion, Buspirone, Enflurane, Theophylline, many narcotics, psychostimulants; Isoniazid (B6 deficiency)

2

Withdrawal causes seizures

Benzos, Barbiturates, Alcohol, Anticonvulsants

3

Stevens-Johnson syndrome

Anticonvulsants (Lamotrigine esp; ethosuximide, carbamazepine, phenobarbital, phenytoin)
Antibiotics (penicillins, sulfa drugs)
Allopurinol

4

Cyp450 inducers (speed up drug metabolism)

[Ken(ytoin) rides shotgun in Barbie's girlie car]
Phenytoin, Rifampin, St. John's Wort, Barbiturates, Griseofulvin, Carbamazepine

5

Cause depression

Sedatives (alcohol, benzos, antihistamines)
Methyldopa
Typical antipsychotics
Anti-nausea drugs (metoclopramide, prochlorperazine), Glucocorticoids
Interferon alfa
Stimulant withdrawal, insufficient thyroid replacement (hypothyroidism)

6

Cause psychosis

Hallucinogens (LSD, PCP)
Stimulants (cocaine, amphetamine)
Withdrawal from benzos, barbiturates, alcohol
Glucocorticoids
Anabolic steroids

7

Check G6PD deficiency to r/o risk of hemolytic anemia

Dapsone

8

Amiodarone

K channel blocker and Na channel blocker (antiarrhythmic medication)
Check PFTs, LFTs, TFTs before use
(Continue to check PFTs - can cause pulmonary fibrosis)

9

Disulfiram like reaction if combined w/ alcohol

Metronidazole

10

Drug-induced lupus

SHIPP
Sulfa drugs (esp sulfasalazine)
Hydralazine
Isoniazid
Phenytoin
Procainamide
(also methyldopa, quinidine, chlorpromazine)

11

Sulfa drugs

Thiazide diuretics
Loop diuretics (except ethacrynic acid)
Acetazolamide

12

Anti-HTN w/ first dose orthostatic HoTN

Alpha blockers

13

Anti-HTN w/ hypertrichosis

Minoxidil

14

Anti-HTN w/ dry mouth, sedation, severe rebound HTN

Clonidine

15

Anti-HTN w/ reflex tachycardia

Vasodilators (hydralazine, minoxidil, nitroprusside)

16

Anti-HTN w/ bradycardia, impotence, asthma exacerbation

Non-selective BB

17

Anti-HTN w/ cough

ACE

18

Anti-HTN w/ angioedema

ACE (maybe ARB)

19

Anti-HTN w/ cyanide toxicity

Nitroprusside (vasodilator)

20

Anti-HTN w/ azotemia, hyperkalemia (C/I)

ACE/ARB

21

Anti-HTN w/ peripheral edema

NDP and DHP CCB (eg amlodipine)

22

Anti-HTN w/ increased intracranial pressure

Nitroprusside (vasodilator)

23

Cyclosporine

(Immunosuppressant)
Nephrotoxicity

24

Azathioprine

(Immunosuppressant)
Leukopenia
Metabolized by XO (so avoid allopurinol)

25

Tacrolimus

(Immunosuppressant)
Nephrotoxicity

26

Muromonab-D3

(Immunosuppressant)
One time cytokine release (leukopenia, fever)
Short-term therapy

27

Rapamycin

(Immunosuppressant)
Thrombocytopenia
Hyperlipidemia

28

Mycophenolate

(Immunosuppressant, lupus nephritis)
Leukopenia
GI toxicity
Lymphoma
Teratogen

29

Antithymocyte globulin

(Immunosuppressant)
Serum sickness
Short-term therapy

30

Hydroxychloroquine

(Immunosuppressant, SLE, RA)
Visual disturbances