HAART

Question 1

NRTI mechanism

Answer 1

Inhibit production of viral DNA from RNA

Question 2

NRTIs (nucleoside)

Answer 2

Abacavir
Emtricitabine
Lamivudine

Question 3

NRTIs (nucleotide)

Answer 3

Zidovudine

Tenofovir

Question 4

NRTI AEs

Answer 4

Lactic acidosis (can be fatal)
Lipodystrophy

Question 5

NNRTI mechanism

Answer 5

Inhibit production of viral DNA from RNA

Question 6

NNRTIs

Answer 6

Efavirenz
Etravirine
Rilpirvirine

Question 7

NNRTI AEs

Answer 7

Rash

Question 8

Protease inhibitor mechanism

Answer 8

Interfere w/ viral replication and cause production of nonfunctional viruses

Question 9

Protease inhibitors

Answer 9

-navir
Atazanavir
Darunavir
Fosamprenavir
Lopinavir
Ritonavir

Question 10

Integrase inhibitor mechanism

Answer 10

Blocks integration of viral genome into host genome

Question 11

Integrase inhibitors

Answer 11

-gravir
Elvitegravir
Raltegravir

Question 12

CCR5 antagonist

Answer 12

Prevents viral entry by blocking CCR5 coreceptor

Maraviroc

Question 13

Fusion inhibitor

Answer 13

Binds glycoprotein 41 blocking HIV virus fusion to CD4 cells

Envuvirtide

Question 14

Antiretroviral w/ possibly fatal hypersensitivity rxn

Answer 14

Abacavir (NRTI)

Question 15

Antiretroviral w/ BM suppression, anemia

Answer 15

Zidovudine (NRTI)

Question 16

Antiretroviral w/ depression, vivid nightmares, teratogen

Answer 16

Efavirenz (NNRTI)

Question 17

Antiretroviral w/ hyperbilirubinemia, jaundice

Answer 17

Atazanavir

Question 18

Protease inhibitor AEs

Answer 18

Hyperglycemia, DM, +TG

GI toxicity

Question 19

Antiretroviral that inhibits P450, “boosts” other drugs

Answer 19

Ritonavir boosts other protease inhibitors

Question 20

Abacavir

Answer 20

NRTI

AE: Possibly fatal hypersensitivity rxn

Question 21

Efavirenz

Answer 21

NNRTI

AE: teratogenic; depression, vivid nightmares

Question 22

Atazanavir

Answer 22

Protease inhibitor

AE: hyperbilirubinemia, jaundice

Question 23

Emtricitabine

Answer 23

NRTI

Question 24

Elvitegravir

Answer 24

Integrase inhibitor

Question 25

Etravirine

Answer 25

NNRTI

Question 26

Darunavir

Answer 26

Protease inhibitor

Question 27

Enfuvirtide

Answer 27

Fusion inhibitor

Question 28

Fosamprenavir

Answer 28

Protease inhibitor

Question 29

Lamivudine

Answer 29

NRTI

Question 30

Rilpirvirine

Answer 30

NNRTI

Question 31

Raltegravir

Answer 31

Integrase inhibitor

Question 32

Tenofovir

Answer 32

NRTI

Question 33

Maraviroc

Answer 33

CCR5 antagonist

Question 34

Zidovudine

Answer 34

NRTI

AE: BM suppression, anemia

Question 35

Lopinavir

Answer 35

Protease inhibitor

Question 36

Ritonavir

Answer 36

Protease inhibitor (booster)