Alcohol - Lichtblau Flashcards Preview

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Flashcards in Alcohol - Lichtblau Deck (11):
1

Alcohol effect on liver

-Increase its oxidative metabolism (can make alcoholics less sensitive to medicines)
- Fat production in liver
-Cirrhosis of liver

2

How does alcohol affect the kidney?

-Its a diuretic, by decreasing ADH secretion from pituitary

3

How does alcohol affect the Gi tract?

Can causes increases in gastric acid secrtion, mucosal irritation

Alcoholism can cause:
-Erosive gastritis
-Factor in pancreatitis
-GI lesion association

4

Why is champagne more rapidly absorbed?

The carbonation decreases gastric emptying time

5

Safe amount to drink during pregnancy?
Safe trimester?

Neither exist! Don't do it!

6

How is disulfiram

Disulfiram interferes with aldehyde dehydrogenase - leads to excessive acetaldehyde levels

7

What is the rate-limiting step of alcohol metabolism?

Metabolism to acetaldehyde, catalyzed by alcohol dehydrogenase

8

What is the antidote to methanol intoxication?

Ethanol!

(competes with metabolism of methanol)

9

REVIEW:
What actually causes the hangover symptoms?

Accumulation of acetaldehyde

10

What is toxicity like with antifreeze consumption?

Early symptoms - 0.5-0.6 hr
-Vomiting
-Depression
-Ataxia
-Weakness
-Convulsions may be followed by coma and death

Late symptoms (for survivors) - 24 hr
Renal failure
-emesis
-dehydration
-weight loss
-weakness
-hematuria
-anuria, possible tonic convulsions, coma and death in 1-3 days

Usual cause of death
-Metabolic acidosis
-cardiovascular dysfunction
-acute kidney failure

11

Naltrexone can be used for what?

Reduce alcohol cravings