Flashcards in Alcohol - Lichtblau Deck (11):
Alcohol effect on liver
-Increase its oxidative metabolism (can make alcoholics less sensitive to medicines)
- Fat production in liver
-Cirrhosis of liver
How does alcohol affect the kidney?
-Its a diuretic, by decreasing ADH secretion from pituitary
How does alcohol affect the Gi tract?
Can causes increases in gastric acid secrtion, mucosal irritation
Alcoholism can cause:
-Factor in pancreatitis
-GI lesion association
Why is champagne more rapidly absorbed?
The carbonation decreases gastric emptying time
Safe amount to drink during pregnancy?
Neither exist! Don't do it!
How is disulfiram
Disulfiram interferes with aldehyde dehydrogenase - leads to excessive acetaldehyde levels
What is the rate-limiting step of alcohol metabolism?
Metabolism to acetaldehyde, catalyzed by alcohol dehydrogenase
What is the antidote to methanol intoxication?
(competes with metabolism of methanol)
What actually causes the hangover symptoms?
Accumulation of acetaldehyde
What is toxicity like with antifreeze consumption?
Early symptoms - 0.5-0.6 hr
-Convulsions may be followed by coma and death
Late symptoms (for survivors) - 24 hr
-anuria, possible tonic convulsions, coma and death in 1-3 days
Usual cause of death
-acute kidney failure