Flashcards in NeuroOncology - Bemis Deck (20):
What do you call a treatment that follows the primary treatment?
(With tumors, adjuvant therapy goal is to remove any residual cancer cells)
Rosenthal fibers and a biphasic pathology pattern are particularly associated with what kind of tumors?
Pretty benign Pilocytic Astrocytoma
What is GFAP?
What does it show?
GFAP = glial fibrillary acidic protein
Indicator of astrocyte injury
What is a key feature of a primary glioblastoma?
Feature of butterfly gliomas?
they cross the midline (via corpus callosum?)
What is the i(17q) mutation associated with?
poor prognosis in medulloblastoma
(short arm of chromosom 17 is completely gone and replaced with another long arm)
Where do you see medulloblastomas?
In children, usually cerebellum
What symptoms do you see with medulloblastoma?
Headache, morning vomiting gets worse with time, problems with back pain and motion
About 70% of brain tumors are metastatic from other sites. How can you tell the different between a primary brain tumor and a metastasis to the brain?
Primary Brain Tumors:
Metastasis to brain:
-Usually located in gray/white matter junction
What is the difference between adults and children as far as the general location of CNS tumors?
Children - 70% of tumors are in the posterior fossa
Adults - 70% of tumors are located in the supratentorial
Describe the general rules for tumor grading in the CNS:
Grade 1: Low prolif potential - just cut it out!
Grade 2: Infiltrative, but low proliferative activity
Grade 3: See more mitosis
Grade 4: Fast progression, active mitosis, necrosis prone
Why are high grade gliomas so hard to treat?
Infiltrative borders make them hard to completely excise
Possible symptoms of glioblastoma?
-Slowly progressing neuro deficit (like motor weakness)
What are the classic features of oligodendrogliomas?
Sharply circumscribed masses
Round nuclei with cytoplasm halo (fried egg)
As you are looking at a pathology slide from a brain neoplasm, you see pseudorosettes and rosettes. Immediately you think:
Must be an ependyoma!
The next path slides you look at reveal Homer-Wright Rosettes... What kind of neoplasm are you thinking of now???
You diagnose a patient with a fairly common benign tumor of arachnoid cells.
What is this neoplasm callded?
What would you see in pathology slides?
You would see a synctial pattern (look like little whirlpools of tissue)
Psammoma bodies (Ca deposits)
What is the most likely time you will see a primary brain lymphoma? (because they are rare)
How do you diagnose it?
In an immuosuppressed patient
Very simple diagnosis in CSF
Relatively common brain tumor that is found often at CN 7. Often get hearing loss and tinnitis.
Name that tumor!