Alcoholic and autoimmune hepatitis

Question 1

What is alcoholic hepatitis?

Answer 1

Fatty change in liver in response to excess alcohol, leading to decompensated hepatic function

Question 2

What are the features of alcoholic hepatitis?

Answer 2

Jaundice
Encephalopathy
History of alcohol

Question 3

What are the investigation results in alcoholic hepatitis?

Answer 3

Raised bilirubin
Raised AST/ALT and GGT 
Raised ALP in later disease
Low albumin and long prothrombin time
US, CT/MRI, biopsy= show fatty change --> fibrosis

Question 4

What is the management of alcoholic hepatitis?

Answer 4

Supportive, high calorie intake

Question 5

What is the management and prognosis of severe alcoholic hepatitis?

Answer 5

Steroids

Poor prognosis

Question 6

Who is autoimmune hepatitis seen in?

Answer 6

Young women

Question 7

What are the clinical features of autoimmune hepatitis?

Answer 7

Asymptomatic
jaundice, fatigue, fever, itch, muscle aches
Other autoimmune conditions

Question 8

What investigations are done for autoimmune hepatitis?

Answer 8

LFTs
IgG
Antibodies- ANA, anti SMA
Liver biopsy

Question 9

What is the management of autoimmune hepatitis?

Answer 9

Steroids

Long term azathioprine