H. pylori and C. diff

Question 1

What % of the population are colonised with H. pylori and will get symptoms?

Answer 1

50% colonised

90% will never get symptoms

Question 2

What can H. pylori cause?

Answer 2

Peptic ulcers
Acute gastritis
Chronic gastritis
GI bleeding

Question 3

What are th features of acute gastritis?

Answer 3

Abdo pain

N&V

Question 4

What are the features of non ulcer gastritis?

Answer 4

Non ulcer dyspepsia-
abdo pain, esp with empty stomach
N&V
Bloating

Question 5

How is H. pylori diagnosed?

Answer 5

Stool antigen test
Urea breath test
Endoscopy

Question 6

How is H. pylori treated?

Answer 6

Triple therapy

• Clairythromycin
• Amoxicillin (metronidazole if allergic)
• PPI

Question 7

How is eradication of H. pylori checked?

Answer 7

Urea breath test

Question 8

What are the complications foe H. pylori?

Answer 8

Increased risk adenocarcinoma

Question 9

What antibiotics are associated with C. diff?

Answer 9

Clindamycin
Ciprofloxacin
Co-amoxiclav
Cephalosporins

Question 10

What are the clinical features of C. diff infection?

Answer 10

Diarrhoea
Abdo pain
Raised WCC

Question 11

What investigations are done to diagnose C. diff?

Answer 11

C diff toxin and antigen in stool

Question 12

What is the management of c. diff infection?

Answer 12

48 hours isolation
1st line= oral metronidazole 10-14 days
2nd line= oral vancomycin

Question 13

What are the complications of c. diff infection?

Answer 13

Peritonitis

Toxic megacolon