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Flashcards in Allergy & Immunology Deck (67)
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Antibody that readily crosses placentA

IgG

1

First antibody produced in an infection

IgM

2

Immunoglobulin that functions in mucosal defense

IgA

3

Immunoglobulin secreted in breast milk

IgA

4

Immunoglobulin involved in allergic reactions and parasitic infections

IgE

5

Protects against intracellular organisms and opportunistic infections

T cells

6

B cell deficiency lead to which type of infections

Recurrent sinopulmonary infections

7

Strep pneumo, H flu, staph aureus, entero virus, giardia

Infections B cell deficient patients are susceptible to

8

Skin and organ abscesses with staph aureus and catalase positive organisms

Phagocytic disorder

9

Blood cx positive for Serratia or Burkholderia

CGD

10

Overwhelming sepsis, pyogenic infection, neisseria meningitis

Complement deficiency

11

SCID, wiskott aldrich, ataxia telangictasia, Bloom syndrome, Nijmegen breakage syndrome

Combined B cell and T cell deficiency

12

Eczema, chronic lung infxn, chronic diarrhea, FTT, absent thymus

SCID

13

No T cells, No NK cells, B cells present

X linked SCID (dx: with flow cytometry and molecular analysis, tx: BMT)

14

No T cells, No B cells, No NK cells

Adenosine Deaminase Deficiency

15

Eczema, immunodeficiency, thrombocytopenia, small platelets

Wiskott Aldrich

16

Mode of inheritance: wiskott Aldrich

X linked

17

Tx Wiskott Aldrich

BMT or ppx abx and IVIG

18

Ataxia, telangiectasia, immunodeficiency

Ataxia Telangiectasia

19

AR defect in ATM gene responsible for DNA repair

Ataxia Telangiectasia

20

Elevated alpha fetoprotein

Ataxia Telangiectasia

21

Immunodeficiency with high risk of cancer (leukemias and lymphomas)

Ataxia Telangiectasia, Bloom Syndrome

22

AR deficiency of DNA ligase 1

Bloom Syndrome

23

Small stature, Telangiectasia, CNS anomalies, immunodeficiency

Bloom Syndrome

24

Bird like face, microcephaly, immunodeficiency, mild MR

Nijmegen Breakage Syndrome

25

Primary T cell deficiency

DiGeorge Syndrome, (have problems with INTRAcellular organisms)

26

Bruton's agammaglobulinemia, CVID, Hyper IgM, Transient hypogammaglobulinemia of infancy, x linked lymphoproliferative syndrome

B cell immunodeficiencies

27

Mutation on BTK gene (Bruton tyrosine kinase)

X linked agammaglobulinemia

28

No mature B cells, no abx present, recurrent ear infxns, sinusitis, PNA

X linked agammaglobulinemia

29

Dx of x linked agammaglobulinemia

Flow cytometry for CD19, response to vaccination.

no mature B cells, no antibodies, no antibody fxn