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Flashcards in Allergy & Immunology Deck (67):
0

Antibody that readily crosses placentA

IgG

1

First antibody produced in an infection

IgM

2

Immunoglobulin that functions in mucosal defense

IgA

3

Immunoglobulin secreted in breast milk

IgA

4

Immunoglobulin involved in allergic reactions and parasitic infections

IgE

5

Protects against intracellular organisms and opportunistic infections

T cells

6

B cell deficiency lead to which type of infections

Recurrent sinopulmonary infections

7

Strep pneumo, H flu, staph aureus, entero virus, giardia

Infections B cell deficient patients are susceptible to

8

Skin and organ abscesses with staph aureus and catalase positive organisms

Phagocytic disorder

9

Blood cx positive for Serratia or Burkholderia

CGD

10

Overwhelming sepsis, pyogenic infection, neisseria meningitis

Complement deficiency

11

SCID, wiskott aldrich, ataxia telangictasia, Bloom syndrome, Nijmegen breakage syndrome

Combined B cell and T cell deficiency

12

Eczema, chronic lung infxn, chronic diarrhea, FTT, absent thymus

SCID

13

No T cells, No NK cells, B cells present

X linked SCID (dx: with flow cytometry and molecular analysis, tx: BMT)

14

No T cells, No B cells, No NK cells

Adenosine Deaminase Deficiency

15

Eczema, immunodeficiency, thrombocytopenia, small platelets

Wiskott Aldrich

16

Mode of inheritance: wiskott Aldrich

X linked

17

Tx Wiskott Aldrich

BMT or ppx abx and IVIG

18

Ataxia, telangiectasia, immunodeficiency

Ataxia Telangiectasia

19

AR defect in ATM gene responsible for DNA repair

Ataxia Telangiectasia

20

Elevated alpha fetoprotein

Ataxia Telangiectasia

21

Immunodeficiency with high risk of cancer (leukemias and lymphomas)

Ataxia Telangiectasia, Bloom Syndrome

22

AR deficiency of DNA ligase 1

Bloom Syndrome

23

Small stature, Telangiectasia, CNS anomalies, immunodeficiency

Bloom Syndrome

24

Bird like face, microcephaly, immunodeficiency, mild MR

Nijmegen Breakage Syndrome

25

Primary T cell deficiency

DiGeorge Syndrome, (have problems with INTRAcellular organisms)

26

Bruton's agammaglobulinemia, CVID, Hyper IgM, Transient hypogammaglobulinemia of infancy, x linked lymphoproliferative syndrome

B cell immunodeficiencies

27

Mutation on BTK gene (Bruton tyrosine kinase)

X linked agammaglobulinemia

28

No mature B cells, no abx present, recurrent ear infxns, sinusitis, PNA

X linked agammaglobulinemia

29

Dx of x linked agammaglobulinemia

Flow cytometry for CD19, response to vaccination.

no mature B cells, no antibodies, no antibody fxn

30

Tx for x linked agammaglobulinemia

IVIG

31

Mature B cells unable to differentiate into plasma cells

CVID

32

Mature B cells present, low antibody levels, poor antibody response

CVID

33

Sprue like illness with diarrhea, malabsorption, steatorrhea

CVID

34

Dx of CVID

Flow cytometry (mature B cells present), check antibody levels/response

35

Susceptible to sinopulmonary bacterial infections and Pneumocystis jiroveci

X linked hyper IgM Syndrome

36

CD40 ligand defect, normal levels IgM, low levels of IgG and IgA

X linked hyper IgM

37

Tx for hyper IgM

BMT or IVIG + Bactrim for PJP ppx

38

Immunodeficiency with near fatal EBV infections, progress to lymphoma

X linked lymphoproliferative syndrome

39

Abnormal prolongation of the physiological hypogammaglobulinemia that occurs between 4 and 6 months of age.

Transient Hypogammaglobulinemia of Infancy

40

Will have normal IgG levels by 4 years, have good vaccine response

Transient Hypogammaglobulinemia of Infancy

41

AR neutropenia

Kostmann syndrome

42

Sterile abscess, delayed separation of umbilical cord, severe leukocytosis, gingivitis, oomphalitis

Leukocyte adhesion defect type 1 (defect in CD18)

43

Elevated IgE, recurrent abscesses, eczema, delayed eruption of primary teeth, pneumatoceles, broad nose, triangular jaw, prominent forehead

Job Syndrome (Hyper IgE)

44

Oculocutaneous albinism, recurrent skin and sinopulmonary infxns, MR, immunodeficiency, peripheral neuropathy

Chediak Higashi

45

Peripheral smear with giant granules

Chediak Higashi

46

Inability to generate respiratory burst

CGD (x linked)

47

Recurrent organ and skin abscesses

CGD

48

Dx of CGD

Dihydrorhodamine oxidation test (DHR). Replaced NBT test

49

Tx of CGD

Ppx abx and interferon gamma

50

Due to defect in C1 inhibitor function

Hereditary Angioedema

51

Hives, allergic rhinitis, asthma, food and latex allergies. IgE mediated

Type 1 Hypersensitivity

52

IgM or IgG antibodies bind to fixed tissue or cell receptors and cause complement activation. Goodpastures, myasthenia gravis, hemolytic anemia

Type 2 hypersensitivity - cytotoxic

53

Vasculitis, serum sickness, arthus reaction. Immune complexes form when antibodies combine with antigen

Type 3 hypersensitivity - Immune Complex

54

Contact dermatitis, tuberculin sensitivity. Sensitized T cells interact with antigen

Type 4 hypersensitivity - delayed hypersensitivity

55

Tx for anaphylaxis patients not responsive to epinephrine (e.g. on beta blockers)

Glucagon or vasopressin

56

Asthma predictive index major criteria

One parent with asthma
Child has eczema

57

Asthma predictive index minor criteria

Child has allergic rhinitis
Child has wheezing apart from colds
Child has eosinophilia

58

Positive Asthma predictive index positive

1 major or 2 minor. If +, 76% of having asthma by 6 yrs. If -, 95% chance of not getting it

59

Asthma predictive index criteria

Children under three, with at least 4 episodes of wheezing

60

Urticaria pigmentosa, tryptase level above 20

Cutaneous mastocytosis

61

IgE mediated drug reaction like anaphylaxis

Type 1 drug reaction

62

Immunoglobulin or antibody mediated reaction like ITP

Type 2 drug reaction

63

Immune complex mediated disorder like serum sickness

Type 3 drug reaction

64

Cell mediated immune reaction like celiac disease

Type 4 drug reaction

65

Foods that cross react with latex

Potato, kiwi, banana, avocado

66

CD18 and CD11

Leukocyte adhesion defect