Alpha-adrenergic blocker (non-selective)

Question 1

Alpha-adrenergic blocker (non-selective) Drug Name

Answer 1

Phenoxybenzamine

Phentolamine

Question 2

Alpha-adrenergic blocker (non-selective) Therapeutic Actions

Answer 2

• Blocks Alpha1 receptors: vasodilation resulting in decreased BP
• Block Alpha2 receptors: prevents norepinephrine feedback loop resulting in increase in reflex tachycardia

Question 3

Alpha-adrenergic blocker (non-selective) Indications

Answer 3

• Diagnose and manage episodes of pheochromocytoma (a tumor that releases hormones that can increase BP)

Question 4

Alpha-adrenergic blocker (non-selective) Contraindications and Cautions

Answer 4

Contraindication:
• Allergy
• CAD
• MI

Question 5

Alpha-adrenergic blocker (non-selective) DDI

Answer 5

• Alcohol

Question 6

Alpha-adrenergic blocker (non-selective) Adverse Effects

Answer 6

•	Increased reflex tachycardia
•	GI effects
•	CNS
•	HA
•	Weakness
•	Dizziness
•	Related to vasodilation and decreased BP
-	Hypotension 
-	Flushing
-	Arrhythmia 
-	Angina

Question 7

Alpha-adrenergic blocker (non-selective):

Assessment

Answer 7

Hx: allergy, contraindications/cautions
Physical: vital signs, weight, BP, RR, abdominal, urinary, perfusion, ECG(baseline)
Labs: electrolyte levels, renal and hepatic function, glucose

Question 8

Alpha-adrenergic blocker (non-selective):

Diagnosis

Answer 8

• Acute pain
• Ineffective tissue perfusion
• Decreased cardiac output
• Risk for injury
• Risk for activity intolerance
• Non-compliance
• Disturbed sensory perception
• Deficient knowledge

Question 9

Alpha-adrenergic blocker (non-selective):

Implementation

Answer 9

• Take apical pulse before: hold if <60bpm
• Do not abruptly stop medication (rebound hypertension)
• Encourage lifestyle changes
• Change positions slowly
• Do not crush ER formulations
• Monitor vitals
• Provide patient teaching

Question 10

Alpha-adrenergic blocker (non-selective):

Evaluation

Answer 10

Response to the drug
Adverse effects
Effectiveness of comfort measures Compliance with the regimen
Effectiveness of the teaching plan