Flashcards in Alzheimer disease Deck (15)
Enhancement of which neurotransmitter is beneficial in AD?
Central acetylcholinesterase inhibitors used in AD - 3 drugs
Donepezil - adverse effects
Diarrhea, GI bleeding, nausea vomiting.
Rivastigmine, galantamine - adverse effects
Bradycardia and AV block.
Nausea, vomiting, anorexia, weight loss.
Rivastigmine - interactions
Nicotine use increases oral clearance.
Galantamine - interactions
Inhibitors of CYP2D6 increase serum levels.
Drugs used for AD - other than central acetylcholinesterase inhibitors - 4 drugs
Memantadine - MOA
Antagonist at NMDA receptors. Attenuates the excitotoxic effects of glutamate.
Memantadine - adverse effects
Confusion, dizziness, drowsiness, headache, insomnia.
Memantadine - interactions
Carbonic anhydrase inhibitors reduce elimination
In AD there is a decrease glucose uptake by the brain. Which drug can help, and MOA
Metabolized into ketone bodies that the brain can use instead of glucose
Caprylidene - indications
Age-associated memory impairment, AD
Dextromethorphan + quinidine - why are they combined for neurodegenerative diseases?
Dextromethorphan: Reduces emotional lability.
Quinidine: inhibits CYP2D6 – increases levels of dextromethorphan which is metabolized by CYP2D6
Dextromethorphan + quinidine: indications
Emotional lability (psuedobulbar affect) in AD, MS, ALS