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24 Neurodegenerative diseases > Huntington disease > Flashcards

Flashcards in Huntington disease Deck (9)
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1

HD - effects of blocking dopamine receptors

Improvement of motor function.
Relieve psychosis.

2

Only drug that may treat chorea in HD

Tetrabenazine

3

Drugs for HD - 3 drugs

Tetrabenazine
Diazepam, benzos
Haloperidol, other antipsychotics.

4

Tetrabenazine - MOA

Reversible inhibition of the human vesicular monoamine transporter type 2 (VMAT2), resulting in decreased uptake of monamines into synaptic vesicles and depletion of monoamine stores (dopamine, serotonin, norepinephrine).

5

Diazepam and benzos- when is it most effective in treatment of HD?

When there are GABA neurons still alive.

6

Diazepam - adverse effects

Arrhythmias
CNS depression
Drug dependence
Hypotension
Mild respiratory depression

7

Diazepam - interactions

Alcohol and other CNS depressant potentiate effects.
Cimetidine increases and rifampin decreases serum levels.

8

Haloperidol - adverse effects

Extrapyramidal side effects and increased prolactin levels.

9

Haloperidol - interactions

Barbiturates and carbamazepine decrease and quinidine increases serum levels